ArticlePharmaceutical research2015
A novel strategy for pharmaceutical cocrystal generation without knowledge of stoichiometric ratio: myricetin cocrystals and a ternary phase diagram.
Article in Pharmaceutical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Thermal Characterization and Heat Capacities of Seven Polyphenols.Molecules (Basel, Switzerland) · 2025Article
- Modulating Pharmaceutical Properties of Berberine Chloride through Cocrystallization with Benzendiol Isomers.Pharmaceutical research · 2023Article
- Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals.Molecules (Basel, Switzerland) · 2023Review
- Imaging supermolecular interactions of the pharmaceutical-cocrystal of apigenin-nicotinamide binding with serum albumin.Turkish journal of chemistry · 2023Article
- A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective.International journal of molecular sciences · 2022Review
- Preparation and Properties of Cyclodextrin Inclusion Complexes ofMolecules (Basel, Switzerland) · 2022Article
- Improving the Physicochemical and Biopharmaceutical Properties of Active Pharmaceutical Ingredients Derived from Traditional Chinese Medicine through Cocrystal Engineering.Pharmaceutics · 2021Review
- Article
- Diclofenac-proline nano-co-crystal development, characterization, in vitro dissolution and diffusion study.Heliyon · 2020Article
- Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions.Foods (Basel, Switzerland) · 2020Article
- Pharmaceutical Co-Crystallization: Regulatory Aspects, Design, Characterization, and Applications.Advanced pharmaceutical bulletin · 2020Review
- Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies.Drug delivery and translational research · 2020Review
- Hydrophobically Modified Glucan as an Amphiphilic Carbohydrate Polymer for Micellar Delivery of Myricetin.Molecules (Basel, Switzerland) · 2019Article
- A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein.Asian journal of pharmaceutical sciences · 2019Article
- The effects of pH, surfactant, ion concentration, coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals.Acta pharmaceutica Sinica. B · 2019Article
- Nonisothermal decomposition and safety parameters of HNIW/TNT cocrystal.RSC advances · 2018Article
- DSC, FTIR and Raman Spectroscopy Coupled with Multivariate Analysis in a Study of Co-Crystals of Pharmaceutical Interest.Molecules (Basel, Switzerland) · 2018Article
- Supramolecular Cocrystals of Gliclazide: Synthesis, Characterization and Evaluation.Pharmaceutical research · 2017Article
- Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development.Advanced pharmaceutical bulletin · 2016Review
- Solid-State and Solution Characterization of Myricetin.AAPS PharmSciTech · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo develop a streamlined strategy for pharmaceutical cocrystal preparation without knowledge of the stoichiometric ratio by preparing and characterizing the cocrystals of myricetin (MYR) with four cocrystal coformers (CCF).
methodsAn approach based on the phase solubility diagram (PSD) was used for MYR cocrystals preparation and the solid-state properties were characterized by differential scanning calorimetry (DSC), fourier transform-infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). The ternary phase diagram (TPD) was constructed by combining the PSD and nuclear magnetic resonance (NMR) data. After that, the TPD was verified by traditional methods. The dissolution of MYR in the four cocrystals and pure MYR within three different media were also evaluated.
resultsA simple research method for MYR cocrystal preparation was obtained as follows: first, the PSD of MYR and CCF was constructed and analyzed; second, by transforming the curve in the PSD to a TPD, a region of pure cocrystals formation was exhibited, and then MYR cocrystals were prepared and identified by DSC, FT-IR, PXRD, and SEM; third, with the composition of the prepared cocrystal from NMR, the TPD of the MYR-CCF-Solvent system was constructed. The powder dissolution data showed that the solubility and dissolution rate of MYR was significantly enhanced by the cocrystals.
conclusionsA novel strategy for pharmaceutical cocrystals preparation without knowledge of the stoichiometric ratio based on the TPD was established and MYR cocrystals were successfully prepared. The present study provides a systematic approach for pharmaceutical cocrystal generation, which benefits the development and application of cocrystal technology in drug delivery.
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