ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2014
Dimorphic fungal osteoarticular infections.
Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bone and joint infections caused by mucormycetes: A challenging osteoarticular mycosis of the twenty-first century.Medical mycology · 2017Pooled it
- Osteoarticular Infections Caused by Non-Aspergillus Filamentous Fungi in Adult and Pediatric Patients: A Systematic Review.Medicine · 2015Pooled it
- Osteoarticular Coccidioidomycosis in California: A Single-Center Experience.Open forum infectious diseases · 2026Article
- Extracutaneous sporotrichosis.Clinical microbiology reviews · 2025Review
- An Extraordinary Case of Prosthetic Joint Infection by Listeria monocytogenes and Histoplasma capsulatum.Cureus · 2025Article
- Metagenomic Next-Generation Sequencing as an Effective Diagnostic Tool for Talaromycosis in HIV-Negative Patients.Mycopathologia · 2024Article
- Genotypic diversity, virulence, and molecular genetic tools inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Disseminated sporotrichosis with osteoarticular involvement in a patient with acquired immunodeficiency syndrome: a case report.Revista da Sociedade Brasileira de Medicina Tropical · 2024Article
- Musculoskeletal manifestations of lower-extremity coccidioidomycosis: a case series.Journal of bone and joint infection · 2024Article
- Endemic mycoses in children in North America: a review of radiologic findings.Pediatric radiology · 2023Review
- Blastomycosis: A Review of Mycological and Clinical Aspects.Journal of fungi (Basel, Switzerland) · 2023Review
- Osteoarticular Mycoses.Clinical microbiology reviews · 2022Review
- Prosthetic Joint Infections Due toMayo Clinic proceedings. Innovations, quality & outcomes · 2021Article
- Characteristics ofAmerican journal of translational research · 2021Article
- Spinal blastomycosis: unusual musculoskeletal presentation with literature review.Skeletal radiology · 2019Review
- Resorbable Beads Provide Extended Release of Antifungal Medication: In Vitro and In Vivo Analyses.Pharmaceutics · 2019Article
- Chronic fungal osteomyelitis of the tibia due toThe Pan African medical journal · 2019Article
- Coccidioides immitis septic knee arthritis.BMJ case reports · 2018Article
- Aspergillus arthritis: analysis of clinical manifestations, diagnosis, and treatment of 31 reported cases.Medical mycology · 2017Article
- Prosthetic Joint Infection Due toOpen forum infectious diseases · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this investigation was to review the clinical manifestations, management, and outcome of osteoarticular infections caused by dimorphic fungi. We exhaustively reviewed reports of bone and joint infections caused by dimorphic fungi published between 1970 and 2012. Underlying conditions, microbiological features, histological characteristics, clinical manifestations, antifungal therapy, and outcome were analyzed in 222 evaluable cases. Among 222 proven cases (median age 41 years [interquartile range (IQR) 26-57]), 73 % had no predisposing condition. Histopathology performed in 128 (57 %) cases and culture in 170 confirmed diagnosis in 63 % and 98 % of the cases, respectively. Diagnosis was obtained from an extra-osteoarticular site in 16 cases. The median diagnostic time was 175 days (IQR 60-365). Sporothrix schenckii was the most frequent pathogen (n = 84), followed by Coccidioides immitis (n = 47), Blastomyces dermatitidis (n = 44), Histoplasma capsulatum (n = 18), Paracoccidioides brasiliensis (n = 16), and Penicillium marneffei (n = 13). Arthritis occurred in 87 (58 %) cases and osteomyelitis in 64 (42 %), including 19 vertebral osteomyelitis. Dissemination was reported in 123 (55 %) cases. Systemic antifungal agents were used in 216 (97 %) patients and in combination with surgery in 129 (60 %). Following the Infectious Diseases Society of America (IDSA) guidelines, a successful initial medical strategy was observed in 97/116 (84 %) evaluable cases. The overall mortality was 6 %, and was highest for P. marneffei (38.5 %). This study demonstrates that dimorphic osteoarticular infections have distinctive clinical presentations, occur predominantly in apparently immunocompetent patients, develop often during disseminated disease, and may require surgical intervention.
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Registered trials
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