ArticleAngewandte Chemie (International ed. in English)2014
Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Involvement of a Noncanonical Polyketide Synthase-Nonribosomal Peptide Synthetase Hybrid in the Biosynthesis of Sterol-C4-methyl Oxidase Inhibitor PF1163A.Organic letters · 2025Article
- Article
- Discovery of Anti-MRSA Secondary Metabolites from a Marine-Derived FungusMarine drugs · 2022Article
- Diversity of the reaction mechanisms of SAM-dependent enzymes.Acta pharmaceutica Sinica. B · 2021Review
- Pseurotin D Inhibits the Activation of Human Lymphocytes.International journal of molecular sciences · 2021Article
- Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Genome-Inspired Chemical Exploration of Marine FungusMarine drugs · 2020Article
- Fumagillin, a Mycotoxin ofToxins · 2019Review
- Oxidative Cyclization in Natural Product Biosynthesis.Chemical reviews · 2017Review
- Physiological characterization of secondary metabolite producingFungal biology and biotechnology · 2017Article
- Dual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation.Frontiers in microbiology · 2017Article
- New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145.The Journal of antibiotics · 2016Article
- Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase.The Journal of antibiotics · 2016Article
- Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.Angewandte Chemie (International ed. in English) · 2016Article
- Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides.Beilstein journal of organic chemistry · 2016Review
- Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis.Organic letters · 2014Article
- Butrepyrazinone, a new pyrazinone with an unusual methylation pattern from a Ghanaian Verrucosispora sp. K51G.Marine drugs · 2014Article
- Endogenous cross-talk of fungal metabolites.Frontiers in microbiology · 2014Review
- A modified recombineering protocol for the genetic manipulation of gene clusters in Aspergillus fumigatus.PloS one · 2014Article
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7 authors.
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Abstract
Pseurotins comprise a family of structurally related Aspergillal natural products having interesting bioactivity. However, little is known about the biosynthetic steps involved in the formation of their complex chemical features. Systematic deletion of the pseurotin biosynthetic genes in A. fumigatus and in vivo and in vitro characterization of the tailoring enzymes to determine the biosynthetic intermediates, and the gene products responsible for the formation of each intermediate, are described. Thus, the main biosynthetic steps leading to the formation of pseurotin A from the predominant precursor, azaspirene, were elucidated. The study revealed the combinatorial nature of the biosynthesis of the pseurotin family of compounds and the intermediates. Most interestingly, we report the first identification of an epoxidase C-methyltransferase bifunctional fusion protein PsoF which appears to methylate the nascent polyketide backbone carbon atom in trans.
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