ArticleBMC complementary and alternative medicine2014
Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Antidiabetic and Anti-Obesity Effects of Betalains: A Systematic Review of Preclinical Evidence.Molecular nutrition & food research · 2026Pooled it
- Biological Activities, Medicinal Uses, and Nutritional Effects ofFood science & nutrition · 2026Review
- Article
- Antioxidant and Antidiabetic Activity of the Bulb Extract ofAntioxidants (Basel, Switzerland) · 2026Article
- Extra Virgin Olive Oil: Molecular Mechanisms, Bioavailability Challenges, and Therapeutic Perspectives.Nutrients · 2026Review
- Extraction of Soybean and Pea Protein Isolates to Evaluate Therapeutic Potential Against Dexamethasone-Induced Osteoporosis: In Vivo andFood science & nutrition · 2026Article
- Comprehensive and updated review on anti-oxidant effects ofIranian journal of basic medical sciences · 2024Review
- In vitro study of Nigella sativa and thymoquinone activity on endothelial activation and monocyte adhesion.Journal of applied biomedicine · 2023Article
- Potential health benefits ofFrontiers in nutrition · 2022Review
- In silico identification of compounds fromBulletin of the National Research Centre · 2021Article
- Effects ofFrontiers in pharmacology · 2021Review
- In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Effects of Nigella sativa L. seed oil on intima-media thickness and Bax and Caspase 3 expression in diabetic rat aorta.Anatolian journal of cardiology · 2016Article
- Rheumatic involvement of the cleft mitral valve.Anatolian journal of cardiology · 2016Article
- The relaxant effect of Nigella sativa on smooth muscles, its possible mechanisms and clinical applications.Iranian journal of basic medical sciences · 2014Review
- Attenuation of morphine tolerance and dependence by thymoquinone in mice.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNigella sativa fixed (NSFO) and essential (NSEO) oils have been used to treat diabetes mellitus and its complications. Present study was undertaken to explore and validate these folkloric uses.
methodsSprague dawley rats having streptozotocin (STZ) induced diabetes mellitus were used to assess the role of NSFO and NSEO in the management of diabetes complications. Parameters investigated were antioxidant potential, oxidative stress, and the immunity by in vivo experiments.
resultsThe results indicated that STZ decreased the glutathione contents (25.72%), while NSFO and NSEO increased the trait significantly (P < 0.05). Experimental diets increased the tocopherol contents (P < 0.01) and enhanced the expression of hepatic enzymes (P < 0.01). Correlation matrix further indicated that antioxidant potential is positively associated (P < 0.05) responsible for the modulation of hepatic enzymes and the decrease of the nitric oxide production thus controlling the diabetes complications.
conclusionsOverall, results of present study supported the traditional use of N. sativa and its derived products as a treatment for hyperglycemia and allied abnormalities. Moreover, N. sativa fixed and essential oils significantly ameliorate free radicals and improve antioxidant capacity thus reducing the risk of diabetic complications.
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