Evidence map›Paper›PMID 24939437›Full record

Trial reportEuropean journal of clinical nutrition2014

α-Tocopherol supplementation reduces biomarkers of oxidative stress in children with Down syndrome: a randomized controlled trial.

S Mustafa Nachvak, T Reza Neyestani, S Ali Mahboob, S Sabour, S Ali Keshawarz, J R Speakman

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. The Role of Oxidative Stress in Trisomy 21 Phenotype.Cellular and molecular neurobiology · 2023
    Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

S Mustafa Nachvak1] Faculty of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran [2] Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.
T Reza NeyestaniNational Nutrition and food technology Research Institute (NNFTRI), Iran.
S Ali MahboobNutrition research Center, Tabriz University of medical sciences, Tabriz, Iran.
S SabourNutrition research Center, Tabriz University of medical sciences, Tabriz, Iran.
S Ali KeshawarzTehran University of Medical Sciences, Tehran, Iran.
J R Speakman1] Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK [2] State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Tabriz University of Medical Sciences · IRInstitute of Genetics and Developmental Biology · CNKermanshah University of Medical Sciences · IRNational Nutrition and Food Technology Research Institute · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDown syndrome (DS) is the most common human chromosomal abnormality. It is characterized by mental retardation and several metabolic disturbances, including elevated oxidative stress, which may be causally linked. Treatment with dietary antioxidants has been suggested as a potential method to alleviate the oxidative damage and retardation of DS patients, but prior supplementation work has been equivocal.

aimTo evaluate the effects of supplementation with antioxidants α-tocopherol and α-lipoic acid (ALA) on oxidative stress biomarkers in DS children.

methodsNinety-three DS children aged 7-15 years from both sexes were randomly allocated to three groups: α-tocopherol (400 IU/day), ALA (100 mg/day) and placebo. The intervention period was 4 months. A healthy control group consisted 26 non-DS siblings. Serum thiobarbituric acid reactive substances (TBARS) and urinary 8-hydroxy-2'-deoxyguanosine (8OHdG) were used as biomarkers of oxidative stress.

resultsDS children had greater levels of baseline oxidative stress than their siblings. Moreover, males had greater levels of 8OHdG than females (P<0.001) but there was no significant association between age and biomarkers of oxidative stress. Serum levels of TBARS did not change significantly over time, or relative to placebo. Although urinary 8OHdG concentrations decreased significantly in both α-tocopherol and ALA, groups compared with the baseline levels (P<0.001), mean final levels of urinary 8OHdG concentrations differed significantly only between α-tocopherol and placebo groups (P<0.01).

conclusionsα-Tocopherol supplementation of the diets of DS children may attenuate oxidative stress at the DNA level.

Indexed as

8-Hydroxy-2'-DeoxyguanosineAdolescentalpha-TocopherolAntioxidantsBiomarkersChildDeoxyguanosineDietary SupplementsDown SyndromeFemaleHumansMaleMalondialdehydeOxidation-ReductionOxidative StressThiobarbituric Acid Reactive Substances8-Hydroxy-2'-Deoxyguanosinealpha-TocopherolAntioxidantsBiomarkersDeoxyguanosineMalondialdehydeThiobarbituric Acid Reactive Substances

Identifiers

PMID24939437
OpenAlexW1972473655

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.