ArticleDeutsches Arzteblatt international2014
Triggers and treatment of anaphylaxis: an analysis of 4,000 cases from Germany, Austria and Switzerland.
Article in Deutsches Arzteblatt international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 166 citations in OpenAlex.
- Declining venom immunotherapy: patient characteristics and clinical outcomes.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- Mechanism of Cardiac Arrest in Fatal Anaphylaxis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- In vitro diagnostics in hymenoptera venom allergy: Current concepts and perspectives.Allergologie select · 2026Review
- Public Information Needs and Interest in Specific Food and Drug Allergy Disorders in Germany (2022-2024): Google Search Engine Analysis.JMIR formative research · 2025Article
- Severe drug-associated anaphylaxis: a complementary descriptive analyses of registry cases and spontaneous reports.European journal of clinical pharmacology · 2025Article
- Clinical Management of Wasp Stings Using Large Language Models: Cross-Sectional Evaluation Study.Journal of medical Internet research · 2025Article
- Exploring the anti-anaphylaxis potential of natural products: A Review.Inflammopharmacology · 2025Review
- Prevalence and Clinical Symptoms of Wheat Allergy in Adults and Adolescents in Central Europe.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Pediatric Anaphylaxis in Emergency Care: A Detailed Analysis of Demographic and Laboratory Findings.Sisli Etfal Hastanesi tip bulteni · 2025Article
- Adrenaline nasal spray in emergency management: An initial expert opinion.Allergologie select · 2025Review
- Management and disease burden of children and adults with severe IgE-mediated food allergy: Are adults the lost population?The World Allergy Organization journal · 2024Article
- Article
- Review
- Using the Right Criteria for MCAS.Current allergy and asthma reports · 2024Review
- Registries in allergy: Structure, target groups, and key findings of allergy-focused registries in Germany.Allergologie select · 2024Article
- Risk Factors for Refractory Anaphylaxis in the Emergency Department.Emergency medicine international · 2024Article
- Occupational anaphylaxis: A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI).Allergologie select · 2024Article
- [Breathing disorders in children].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2023Review
- A Puzzling Mast Cell Trilogy: Anaphylaxis, MCAS, and Mastocytosis.Diagnostics (Basel, Switzerland) · 2023Review
- [Emergencies-Infinite worlds? : Extended reality as a medium in the education, continuing and advanced training in emergency medicine].Die Anaesthesiologie · 2023Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on byIn reply.2015
Authors and funding
18 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnaphylaxis is the most severe manifestation of a mast cell-dependent immediate reaction and may be fatal. According to data from the Berlin region, its incidence is 2-3 cases per 100 000 persons per year.
methodWe evaluated data from the anaphylaxis registry of the German-speaking countries for 2006-2013 and data from the protocols of the ADAC air rescue service for 2010-2011 to study the triggers, clinical manifestations, and treatment of anaphylaxis.
resultsThe registry contained data on 4141 patients, and the ADAC air rescue protocols concerned 1123 patients. In the registry, the most common triggers for anaphylaxis were insect venom (n = 2074; 50.1%), foods (n = 1039; 25.1%), and drugs (n = 627; 15.1%). Within these groups, the most common triggers were wasp (n = 1460) and bee stings (n = 412), legumes (n = 241), animal proteins (n = 225), and analgesic drugs (n = 277). Food anaphylaxis was most frequently induced by peanuts, cow milk, and hen's egg in children and by wheat and shellfish in adults. An analysis of the medical emergency cases revealed that epinephrine was given for grade 3 or 4 anaphylaxis to 14.5% and 43.9% (respectively) of the patients in the anaphylaxis registry and to 19% and 78% of the patients in the air rescue protocols.
conclusionWasp and bee venom, legumes, animal proteins, and analgesic drugs were the commonest triggers of anaphylaxis. Their relative frequency was age-dependent. Epinephrine was given too rarely, as it is recommended in the guidelines for all cases of grade 2 and above.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.