ArticleBreast cancer research and treatment2014
Incident comorbidities and all-cause mortality among 5-year survivors of Stage I and II breast cancer diagnosed at age 65 or older: a prospective-matched cohort study.
Article in Breast cancer research and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between cancer survivorship and subsequent respiratory disease: a systematic literature review.BMJ open respiratory research · 2025Pooled it
- Effect of an anti-inflammatory dietary intervention on quality of life among breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Trial
- Quality of life outcomes from a randomized controlled trial of patient navigation in Latina breast cancer survivors.Cancer medicine · 2020Trial
- Risks of adverse respiratory outcomes in adults with cancer over the course of survivorship compared with cancer-free individuals: a matched cohort study using linked English electronic health records.EClinicalMedicine · 2026Article
- Survivorship Issues in Older Adults with Breast Cancer.Current breast cancer reports · 2025Article
- Risk of atherosclerotic cardiovascular disease after cancer diagnosis: findings from 3 prospective cohort studies.Journal of the National Cancer Institute · 2025Article
- Non-cancer risks among female breast cancer survivors: a matched cohort study in Japan.The Lancet regional health. Western Pacific · 2025Article
- Evaluating the risk of comorbidity onset in elderly patients after a cancer diagnosis.BMC public health · 2025Article
- A Prospective Study of Sentinel Node Biopsy Omission in Women Age ≥ 65 Years with ER+ Breast Cancer.Annals of surgical oncology · 2024Observational
- Multimorbidity in people living with and beyond cancer: a scoping review.American journal of cancer research · 2023Article
- Article
- Trajectories of objectively measured physical function among older breast cancer survivors in comparison with cancer-free controls.Breast cancer research and treatment · 2022Article
- Review
- Survival Differences in Chinese Versus White Women With Breast Cancer in the United States: A SEER-Based Analysis.JCO global oncology · 2020Article
- Article
- Adjuvant chemotherapy-associated lipid changes in breast cancer patients: A real-word retrospective analysis.Medicine · 2020Article
- The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients.NPJ breast cancer · 2020Article
- Article
- Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases.Lancet (London, England) · 2019Article
- Type 2 diabetes as a predictor of survival among breast cancer patients: the multiethnic cohort.Breast cancer research and treatment · 2019Article
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Authors and funding
13 authors.
Funding
Abstract
Five-year breast cancer survivors, diagnosed after 65 years of age, may develop more incident comorbidities than similar populations free of cancer. We investigated whether older breast cancer survivors have a similar comorbidity burden 6-15 years after cancer diagnosis to matched women free of breast cancer at start of follow-up and whether incident comorbidities are associated with all-cause mortality. In this prospective cohort study, 1,361 older 5-year early-stage breast cancer survivors diagnosed between 1990 and 1994 and 1,361 age- and health system-matched women were followed for 10 years. Adjudicated medical record review captured prevalent and incident comorbidities during follow-up or until death as collected from the National Death Index. Older 5-year breast cancer survivors did not acquire incident comorbidities more often than matched women free of breast cancer in the subsequent 10 years [hazard ratio (HR) 1.0, 95 % confidence interval (95 % CI) 0.93, 1.1]. Adjusted for cohort membership, women with incident comorbidities had a higher mortality rate than those without incident comorbidities (HR 4.8, 95 % CI 4.1, 5.6). A breast cancer history continued to be a hazard for mortality 6-15 years after diagnosis (HR 1.3, 95 % CI 1.1, 1.4). We found that older breast cancer survivors who developed comorbidities had an increased all-cause mortality rate even after adjusting for age and prevalent comorbidity burden. Additionally, survivors acquire comorbidities at a rate similar to older women free of breast cancer. These results highlight the association between comorbidity burden and long-term mortality risk among older breast cancer survivors and their need for appropriate oncology and primary care follow-up.
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