ArticleBrain stimulation
High frequency stimulation extends the refractory period and generates axonal block in the rat hippocampus.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Bifurcation of neural firing patterns driven by potassium dynamics and neuron-electrode geometry during high-frequency stimulation.PLoS computational biology · 2026Article
- Optimal Frequency for Seizure Induction With Electroconvulsive Therapy and Magnetic Seizure Therapy in Nonhuman Primates.Biological psychiatry global open science · 2025Article
- Neural Mechanisms Underlying Robust Target Selection in Response to Microstimulation of the Oculomotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Therapeutic Frequency Profile of Subthalamic Nucleus Deep Brain Stimulation in Rats Is Shaped by Antidromic Spike Failure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- The cortical evoked potential corresponds with deep brain stimulation efficacy in rats.Journal of neurophysiology · 2022Article
- An Anodic Phase Can Facilitate Rather Than Weaken a Cathodic Phase to Activate Neurons in Biphasic-Pulse Axonal Stimulations.Frontiers in neuroscience · 2022Article
- Suppression of Neuronal Firing Following Antidromic High-Frequency Stimulations on the Neuronal Axons in Rat Hippocampal CA1 Region.Frontiers in neuroscience · 2022Article
- Different effects of monophasic pulses and biphasic pulses applied by a bipolar stimulation electrode in the rat hippocampal CA1 region.Biomedical engineering online · 2021Article
- Suppressing synchronous firing of epileptiform activity by high-frequency stimulation of afferent fibers in rat hippocampus.CNS neuroscience & therapeutics · 2021Article
- The Appearance Order of Varying Intervals Introduces Extra Modulation Effects on Neuronal Firing Through Non-linear Dynamics of Sodium Channels During High-Frequency Stimulations.Frontiers in neuroscience · 2020Article
- Selective modulation of neuronal firing by pulse stimulations with different frequencies in rat hippocampus.Biomedical engineering online · 2019Article
- On the parameters used in finite element modeling of compound peripheral nerves.Journal of neural engineering · 2019Article
- Small Changes in Inter-Pulse-Intervals Can Cause Synchronized Neuronal Firing During High-Frequency Stimulations in Rat Hippocampus.Frontiers in neuroscience · 2019Article
- Design of a novel stimulation system with time-varying paradigms for investigating new modes of high frequency stimulation in brain.Biomedical engineering online · 2018Article
- Simulation Study of Intermittent Axonal Block and Desynchronization Effect Induced by High-Frequency Stimulation of Electrical Pulses.Frontiers in neuroscience · 2018Article
- Axonal Stimulations With a Higher Frequency Generate More Randomness in Neuronal Firing Rather Than Increase Firing Rates in Rat Hippocampus.Frontiers in neuroscience · 2018Article
- Novel Stimulation Paradigms with Temporally-Varying Parameters to Reduce Synchronous Activity at the Onset of High Frequency Stimulation in Rat Hippocampus.Frontiers in neuroscience · 2017Article
- Mechanisms of Neurostimulation for Epilepsy.Epilepsy currentsArticle
- Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy.Basic and clinical neuroscienceReview
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe therapeutic mechanisms of deep brain stimulations (DBS) are not fully understood. Axonal block induced by high frequency stimulation (HFS) has been suggested as one possible underlying mechanism of DBS.
objectiveTo investigate the mechanism of the generation of HFS-induced axonal block.
methodsHigh frequency pulse trains were applied to the fiber tracts of alveus and Schaffer collaterals in the hippocampal CA1 neurons in anaesthetized rats at 50, 100 and 200 Hz. The amplitude changes of antidromic-evoked population spikes (APS) were measured to determine the degree of axonal block. The amplitude ratio of paired-pulse evoked APS was used to assess the changes of refractory period.
resultsThere were two distinct recovery stages of axonal block following the termination of HFS. One frequency-dependent faster phase followed by another frequency-independent slower phase. Experiments with specially designed temporal patterns of stimulation showed that HFS produced an extension of the duration of axonal refractory period thereby causing a fast recovery phase of the axonal block. Thus, prolonged gaps inserted within HFS trains could eliminate the axonal block and induced large population spikes and even epileptiform activity in the upstream or downstream regions.
conclusionsExtension of refractory period plays an important role on HFS induced axonal block. Stimulation pattern with properly designed pauses could be beneficial for different requirements of excitation or inhibition in DBS therapies.
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