Trial reportAddiction (Abingdon, England)2014
The relationship between years of cocaine use and brain activation to cocaine and response inhibition cues.
Trial report in Addiction (Abingdon, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03220776 (Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics
Who cites it
23 citing papers in PubMed, 85 citations in OpenAlex.
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- The Incentive-Sensitization Theory of Addiction 30 Years On.Annual review of psychology · 2025Review
- Discriminative functional connectivity signature of cocaine use disorder links to rTMS treatment response.Nature. Mental health · 2024Article
- Separating desire from prediction of outcome value.Trends in cognitive sciences · 2023Review
- A generalizable functional connectivity signature characterizes brain dysfunction and links to rTMS treatment response in cocaine use disorder.medRxiv : the preprint server for health sciences · 2023Article
- A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus.Nature protocols · 2022Article
- Alteration of Behavioral Inhibitory Control in High-Altitude Immigrants.Frontiers in behavioral neuroscience · 2021Article
- Neurofunctional Differences Related to Methamphetamine and Sexual Cues in Men With Shorter and Longer Term Abstinence Methamphetamine Dependence.The international journal of neuropsychopharmacology · 2020Article
- Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study.BMC neuroscience · 2019Article
- Neural correlates of oxytocin and cue reactivity in cocaine-dependent men and women with and without childhood trauma.Psychopharmacology · 2019Article
- Classification of cocaine-dependent participants with dynamic functional connectivity from functional magnetic resonance imaging data.Journal of neuroscience research · 2019Article
- The importance of considering polysubstance use: lessons from cocaine research.Drug and alcohol dependence · 2018Review
- Current perspectives on incentive salience and applications to clinical disorders.Current opinion in behavioral sciences · 2018Article
- Differential Activation of the Left and Right Cerebral Hemispheres of Individuals Who Use or are Dependent on Drugs of Abuse.Journal of drug abuse · 2018Article
- Liking, wanting, and the incentive-sensitization theory of addiction.The American psychologist · 2016Article
- Neural Correlates of Exposure to Cocaine Cues in Rhesus Monkeys: Modulation by the Dopamine Transporter.Biological psychiatry · 2016Article
- Effects of cognitive load on neural and behavioral responses to smoking-cue distractors.Cognitive, affective & behavioral neuroscience · 2016Article
- Laterality of Brain Activation for Risk Factors of Addiction.Current drug abuse reviews · 2016Review
- Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Recent Insights into the Neurobiology of Impulsivity.Current addiction reports · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
aimsFunctional magnetic resonance imaging research has attempted to elucidate the neurobehavioral underpinnings of cocaine dependence by evaluating differences in brain activation to cocaine and response inhibition cues between cocaine-dependent individuals and controls. This study investigated associations between task-related brain activation and cocaine use characteristics.
designCross-sectional.
settingThe Center for Biomedical Imaging at the Medical University of South Carolina, USA.
participantsFifty-one cocaine users (41 dependent). MEASUREMENTS: Brain activation to cocaine-cue exposure and Go No-Go tasks in six a priori selected brain regions of interest and cocaine use characteristics (i.e. cocaine dependence status, years of cocaine use, cocaine use in the past 90 days) assessed via standardized interviews.
findingsParticipants demonstrated elevated activation to cocaine (bilateral ventral striatum, dorsal caudate, amygdala) and response inhibition (bilateral anterior cingulate, insula, inferior frontal gyrus) cues in all hypothesized brain regions. Years of cocaine use was associated with task-related brain activation, with more years of cocaine use associated with greater activation to cocaine cues in right (F = 7.97, P = 0.01) and left (F = 5.47, P = 0.02) ventral striatum and greater activation to response inhibition cues in left insula (F = 5.10, P = 0.03) and inferior frontal gyrus (F = 4.12, P = 0.05) controlling for age, cocaine dependence status and cocaine use in the past 90 days.
conclusionsYears of cocaine use may be more centrally related to cocaine cue and response inhibition brain activation than cocaine dependence diagnosis or amount of recent use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.