Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014
Circadian and homeostatic modulation of functional connectivity and regional cerebral blood flow in humans under normal entrained conditions.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Variability of physiological brain perfusion in healthy subjects - A systematic review of modifiers. Considerations for multi-center ASL studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- Neuronal nitric oxide synthase regulates regional brain perfusion in healthy humans.Cardiovascular research · 2022Trial
- Modulatory effects of ketamine, risperidone and lamotrigine on resting brain perfusion in healthy human subjects.Psychopharmacology · 2015Trial
- Diurnal Variations and Test-Retest Reliability of Resting-State Functional MRI Metrics.Human brain mapping · 2026Article
- Human Cerebral Blood Flow Activity with Diurnal Variation Differentially Correlated with the Suprachiasmatic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Diurnal variation in neurovascular coupling and the impact of sleep quality: a UK Biobank study.Sleep · 2026Article
- Therapeutic Potential of Anesthesiology for Sleep Disorders in the Perioperative Period.Current neuropharmacology · 2026Review
- Chronotype, cognitive outcomes, and neural dynamics: recent evidence and potential mechanisms with implications for perioperative period.Frontiers in neuroscience · 2025Review
- Mapping the Connection Between Circadian Rhythms, Metabolism, and Neurodegeneration: Exploring Therapeutic Strategies.Current Alzheimer research · 2025Review
- Challenges in measuring individual differences of brain function.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Longitudinal single-subject neuroimaging study reveals effects of daily environmental, physiological, and lifestyle factors on functional brain connectivity.PLoS biology · 2024Article
- Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure.Circulation research · 2024Review
- Circadian and Diurnal Regulation of Cerebral Blood Flow.Circulation research · 2024Review
- Diurnal oscillations of MRI metrics in the brains of male participants.Nature communications · 2023Article
- Molecular-enriched functional connectivity in the human brain using multiband multi-echo simultaneous ASL/BOLD fMRI.Scientific reports · 2023Article
- Test-Retest Reliability of Resting Brain Small-World Network Properties across Different Data Processing and Modeling Strategies.Brain sciences · 2023Article
- Decreased Functional Connectivity of Brain Networks in the Alpha Band after Sleep Deprivation Is Associated with Decreased Inhibitory Control in Young Male Adults.International journal of environmental research and public health · 2023Article
- Temporal Stability of the Dynamic Resting-State Functional Brain Network: Current Measures, Clinical Research Progress, and Future Perspectives.Brain sciences · 2023Article
- Development of circadian neurovascular function and its implications.Frontiers in neuroscience · 2023Review
- Time of day dependent longitudinal changes in resting-state fMRI.Frontiers in neurology · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diurnal rhythms have been observed in human behaviors as diverse as sleep, olfaction, and learning. Despite its potential impact, time of day is rarely considered when brain responses are studied by neuroimaging techniques. To address this issue, we explicitly examined the effects of circadian and homeostatic regulation on functional connectivity (FC) and regional cerebral blood flow (rCBF) in healthy human volunteers, using whole-brain resting-state functional magnetic resonance imaging (rs-fMRI) and arterial spin labeling (ASL). In common with many circadian studies, we collected salivary cortisol to represent the normal circadian activity and functioning of the hypothalamic-pituitary-adrenal (HPA) axis. Intriguingly, the changes in FC and rCBF we observed indicated fundamental decreases in the functional integration of the default mode network (DMN) moving from morning to afternoon. Within the anterior cingulate cortex (ACC), our results indicate that morning cortisol levels are negatively correlated with rCBF. We hypothesize that the homeostatic mechanisms of the HPA axis has a role in modulating the functional integrity of the DMN (specifically, the ACC), and for the purposes of using fMRI as a tool to measure changes in disease processes or in response to treatment, we demonstrate that time of the day is important when interpreting resting-state data.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.