ArticleAnais brasileiros de dermatologia
Factors that influence healing of chronic venous leg ulcers: a retrospective cohort.
Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Skin Substitutes for Adults With Diabetic Foot Ulcers and Venous Leg Ulcers: A Health Technology Assessment.Ontario health technology assessment series · 2021Pooled it
- Protease activity as a prognostic factor for wound healing in venous leg ulcers.The Cochrane database of systematic reviews · 2018Pooled it
- Bacterial cellulose an effective material in the treatment of chronic venous ulcers of the lower limbs.Journal of materials science. Materials in medicine · 2021Trial
- The Effectiveness of Advanced Practice Nurses with Respect to Complex Chronic Wounds in the Management of Venous Ulcers.International journal of environmental research and public health · 2019Trial
- Pilot study of homologous platelet gel in venous ulcers.Anais brasileiros de dermatologiaTrial
- Clinical history of venous leg ulcers: a retrospective analysis of 352 cases.Postepy dermatologii i alergologii · 2026Article
- Rétrograde venous perfusion (RVP) for intraçtable venous leg ulcers: a retrospective analysis.European journal of medical research · 2025Article
- Single-center clinical experience of cyanoacrylate embolization method for incompetent perforating veins in treating CEAP-6 patients.Journal of vascular surgery. Venous and lymphatic disorders · 2024Article
- Understanding CEAP Classification: Insights from an Italian Survey on Corona Phlebectatica and Recurrent Active Venous Ulcers by Vascular Specialists.Medicina (Kaunas, Lithuania) · 2024Article
- Cost-effectiveness analysis of intralesional and perilesional recombinant human epidermal growth factor vs hydrocolloid therapy in venous ulcer treatment in the Colombian context.Journal of vascular surgery. Venous and lymphatic disorders · 2024Review
- Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing.Biomimetics (Basel, Switzerland) · 2023Review
- Orthopaedic applications of cold physical plasma.EFORT open reviews · 2023Review
- Analysis of data with dependent measures in clinical and experimental studies.Jornal vascular brasileiro · 2023Article
- RESVECH 2.0: cross-cultural adaptation for Brazil, reliability and validity for the evaluation of venous ulcers.Revista brasileira de enfermagem · 2023Article
- Development of a model to predict closure of chronic wounds in Germany: Claims data analysis.International wound journal · 2022Article
- Dimensionality and psychometric analysis of DLQI in a Brazilian population.Health and quality of life outcomes · 2020Article
- Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine.International journal of molecular sciences · 2020Review
- Kikuhime Device in the Management of Venous Leg Ulcers.Clinical interventions in aging · 2020Article
- Potential prognostic factors for delayed healing of common, non-traumatic skin ulcers: A scoping review.International wound journal · 2019Article
- Health-related quality of life in patients with venous leg ulcer treated in primary care in Brazil and Portugal.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVenous ulcers have a significant impact on patient quality of life, and constitute a worldwide public health problem. Treatment is complex, with high failure rates.
objectivesTo identify clinical and therapeutic factors that influence healing of venous ulcers.
methodsRetrospective cohort study of patients with venous ulcers. Ulcer area was measured at the first visit (T0) and after 6 months (T6) and 1 year (T12). A reduction in ulcer area of 50% or more at T6 and T12 was the outcome of interest, weighted by clinical, demographic and treatment aspects.
resultsNinety-four patients were included (137 ulcers). A reduction in ulcer area of 50% or more was seen in 40.1% of patients (95%CI 31.9 to 48.4%) at T6 and 49.6% (95%CI 41.2 to 58.1%) at T12. Complete healing occurred in 16.8% (95%CI 10.5 to 23.1%) at T6 and 27% (95%CI 19.5 to 39.5%) at T12. The lowest ulcer area reductions at T6 were associated with longstanding ulcer (RR=0.95; 95%CI 0.91 to 0.98), poor adherence to compression therapy (RR=4.04; 95%CI 1.31 to 12.41), and infection episodes (RR=0.42; 95%CI 0.23 to 0.76). At T12, lower reductions were associated with longstanding ulcer (RR=0.95; 95%CI 0.92 to 0.98), longer topical antibiotic use (RR=0.93; 95%CI 0.87 to 0.99), and systemic antibiotic use (RR=0.63; 95%CI 0.40 to 0.99).
conclusionsLongstanding ulcer, infection, poor adherence to compression therapy, and longer topical and systemic antibiotic use were independently correlated with worse healing rates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.