ArticlePloS one2014
Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
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- Expression and epitope prediction of MPT64 recombinant proteins from clinical isolates ofVeterinary world · 2022Article
- Methods for conducting trends analysis: roadmap for comparing outcomes from three national HIV Population-based household surveys in Kenya (2007, 2012, and 2018).BMC public health · 2022Article
- Role of community-based active case finding in screening tuberculosis in Yunnan province of China.Infectious diseases of poverty · 2019Article
- Bayesian modeling of spatiotemporal patterns of TB-HIV co-infection risk in Kenya.BMC infectious diseases · 2019Article
- Space-time clustering of recently-diagnosed tuberculosis and impact of ART scale-up: Evidence from an HIV hyper-endemic rural South African population.Scientific reports · 2019Article
- Observational
- Assessing the impact of antiretroviral therapy on tuberculosis notification rates among people with HIV: a descriptive analysis of 23 countries in sub-Saharan Africa, 2010-2015.BMC infectious diseases · 2018Article
- Spatial overlap links seemingly unconnected genotype-matched TB cases in rural Uganda.PloS one · 2018Article
- Survival of people living with HIV who defaulted from tuberculosis treatment in a cohort, Recife, Brazil.BMC infectious diseases · 2017Article
- Reduction of HIV-associated excess mortality by antiretroviral treatment among tuberculosis patients in Kenya.PloS one · 2017Article
- Vaccine research and development: tuberculosis as a global health threat.Central-European journal of immunology · 2017Review
- Scale-up of ART in Malawi has reduced case notification rates in HIV-positive and HIV-negative tuberculosis.Public health action · 2016Article
- Implementation and Operational Research: Declining Tuberculosis Incidence Among People Receiving HIV Care and Treatment Services in East Africa, 2007-2012.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Temporal trends in TB notification rates during ART scale-up in Cape Town: an ecological analysis.Journal of the International AIDS Society · 2015Article
- What's next for tuberculosis control in sub-Saharan Africa?Public health action · 2014Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Kenya, the comparative incidences of tuberculosis among persons with and without HIV have not been described, and the differential impact of public health interventions on tuberculosis incidence in the two groups is unknown.
methodsWe estimated annual tuberculosis incidence stratified by HIV status during 2006-2012 based on the numbers of reported tuberculosis patients with and without HIV infection, the prevalence of HIV infection in the general population, and the total population. We also made crude estimates of annual tuberculosis incidence stratified by HIV status during 1998-2012 by assuming a constant ratio of HIV prevalence among tuberculosis patients compared to the general population.
resultsTuberculosis incidence among both adults with HIV and adults without HIV increased during 1998-2004 then remained relatively stable until 2007. During 2007-2012, tuberculosis incidence declined by 28-44% among adults with HIV and by 11-26% among adults without HIV, concurrent with an increase in antiretroviral therapy uptake. In 2012, tuberculosis incidence among adults with HIV (1,839-1,936 cases/100,000 population) was still eight times as high as among adults without HIV (231-238 cases/100,000 population), and approximately one third of tuberculosis cases were attributable to HIV.
conclusionsAlthough tuberculosis incidence has declined among adults with and without HIV, the persistent high incidence of tuberculosis among those with HIV and the disparity between the two groups are concerning. Early diagnosis of HIV, early initiation of antiretroviral therapy, regular screening for tuberculosis, and isoniazid preventive therapy among persons with HIV, as well as tuberculosis control in the general population, are required to address these issues.
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