ArticlePloS one2014
Antioxidant capacities, phenolic profile and cytotoxic effects of saxicolous lichens from trans-Himalayan cold desert of Ladakh.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 66 citations in OpenAlex.
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- Antioxidant and Antidiabetic Potential of the Antarctic LichenAntioxidants (Basel, Switzerland) · 2025Article
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- A spectrophotometric analysis of extracted water-soluble phenolic metabolites of lichens.Planta · 2024Article
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- Cytotoxic, anti-proliferative, and apoptotic evaluation of Ramalina sinensis (Ascomycota, Lecanoromycetes), lichenized fungus on oral squamous cell carcinoma cell line; in-vitro study.BMC complementary medicine and therapies · 2023Article
- Antioxidant and antimicrobial activities and GC/MS-based phytochemical analysis of two traditional Lichen species Trypethellium virens and Phaeographis dendritica.Journal, genetic engineering & biotechnology · 2023Article
- Phytochemical Analysis, Antioxidant, Antimicrobial, and Cytotoxic Activity of Different Extracts ofPlants (Basel, Switzerland) · 2022Article
- A Comparative Study of Isolated Secondary Metabolites from Lichens and Their Antioxidative Properties.Plants (Basel, Switzerland) · 2022Article
- Antimicrobial and antioxidant potentials of non-cytotoxic extracts of corticolous lichens sampled in Armenia.AMB Express · 2021Article
- Effects of FermentedJournal of nutrition and metabolism · 2021Article
- Metabolite Profiling of the Indian Food Spice Lichen,Frontiers in pharmacology · 2021Article
- Anticancer Potential of Lichens' Secondary Metabolites.Biomolecules · 2020Review
- Protective effects of Phyllanthus phillyreifolius extracts against hydrogen peroxide induced oxidative stress in HEK293 cells.PloS one · 2018Article
- Anti-inflammatory and anti-insulin resistance activities of aqueous extract fromFood science & nutrition · 2017Article
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- Antioxidant and proapoptotic activities of Sclerocarya birrea [(A. Rich.) Hochst.] methanolic root extract on the hepatocellular carcinoma cell line HepG2.BioMed research international · 2015Article
- Chemical composition and biological activities of trans-Himalayan alga Spirogyra porticalis (Muell.) Cleve.PloS one · 2015Article
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8 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Fourteen saxicolous lichens from trans-Himalayan Ladakh region were identified by morpho-anatomical and chemical characteristics. The n-hexane, methanol and water extracts of the lichens were evaluated for their antioxidant capacities. The lichen extracts showing high antioxidant capacities and rich phenolic content were further investigated to determine their cytotoxic activity on human HepG2 and RKO carcinoma cell lines. The ferric reducing antioxidant power (FRAP), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) radical scavenging capacities and β-carotene-linoleic acid bleaching property exhibited analogous results where the lichen extracts showed high antioxidant action. The lichen extracts were also found to possess good amount of total proanthocyanidin, flavonoid and polyphenol. The methanolic extract of Lobothallia alphoplaca exhibited highest FRAP value. Methanolic extract of Xanthoparmelia stenophylla showed the highest ABTS radical scavenging capacity. The n-hexane extract of Rhizoplaca chrysoleuca exhibited highest DPPH radical scavenging capacity. Highest antioxidant capacity in terms of β-carotene linoleic acid bleaching property was observed in the water extract of Xanthoria elegans. Similarly, Melanelia disjuncta water extract showed highest NO scavenging capacity. Among n-hexane, methanol and water extracts of all lichens, the methanolic extract of Xanthoparmelia mexicana showed highest total proanthocyanidin, flavonoid and polyphenol content. From cytotoxic assay, it was observed that the methanolic extracts of L. alphoplaca and M. disjuncta were exhibiting high cytotoxic effects against cancer cell growth. Similarly, the water extract of Dermatocarpon vellereum, Umbilicaria vellea, X. elegans and M. disjuncta and the methanolic extract of M. disjuncta and X. stenophylla were found to possess high antioxidant capacities and were non-toxic and may be used as natural antioxidants for stress related problems. Our studies go on to prove that the unique trans-Himalayan lichens are a hitherto untapped bioresource with immense potential for discovery of new chemical entities, and this biodiversity needs to be tapped sustainably.
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