Evidence map›Paper›PMID 24937665›Full record

ArticleBritish journal of cancer2014

Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

M Obón-Santacana, R Kaaks, N Slimani, L Lujan-Barroso, H Freisling, P Ferrari, L Dossus, N Chabbert-Buffet, L Baglietto, R T Fortner and 33 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
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  8. Dietary intake of acrylamide and epithelial ovarian cancer risk in the european prospective investigation into cancer and nutrition (EPIC) cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 11 countries.

M Obón-SantacanaUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Avda Gran Via Barcelona 199-203, 08908L'Hospitalet de Llobregat, Barcelona, Spain.
R KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany.
N SlimaniDietary Exposure Assessment Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69372, France.
L Lujan-BarrosoUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Avda Gran Via Barcelona 199-203, 08908L'Hospitalet de Llobregat, Barcelona, Spain.
H FreislingDietary Exposure Assessment Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69372, France.
P FerrariNutritional Epidemiology Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69372, France.
L Dossus1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Paris-Sud University, UMRS 1018, F-94805 Villejuif, France [3] Institut Gustave Roussy, F-94805 Villejuif, France.
N Chabbert-Buffet1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Paris-Sud University, UMRS 1018, F-94805 Villejuif, France [3] Institut Gustave Roussy, F-94805 Villejuif, France [4] Obstetrics and Gynecology Department AP-HP, Hopital Tenon, F-75020 Paris, France.
L Baglietto1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia [2] Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC, Australia.
R T FortnerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany.
H BoeingDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114/116, Nuthetal 14558, Germany.
A TjønnelandDanish Cancer Society Research Center, Strandboulevarden 49, Copenhagen 2100, Denmark.
A OlsenDanish Cancer Society Research Center, Strandboulevarden 49, Copenhagen 2100, Denmark.
K OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, Nordre Ringgade 1, Aarhus 8000, Denmark.
V MenéndezPublic Health and Participation Directorate, Ciriaco Miguel Vigil 9, Asturias 33009, Spain.
E Molina-MontesCIBER Epidemiology and Public Health CIBERESP, Melchor Fernández Almagro 3-5, Madrid 28029, Spain.
N Larrañaga1] CIBER Epidemiology and Public Health CIBERESP, Melchor Fernández Almagro 3-5, Madrid 28029, Spain [2] Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, Avda. Navarra, 4, San Sebastian 20013, Spain.
M-D Chirlaque1] CIBER Epidemiology and Public Health CIBERESP, Melchor Fernández Almagro 3-5, Madrid 28029, Spain [2] Department of Epidemiology, Murcia Regional Health Authority, Ronda de Levante, 11, Murcia 30008, Spain.
E Ardanaz1] CIBER Epidemiology and Public Health CIBERESP, Melchor Fernández Almagro 3-5, Madrid 28029, Spain [2] Navarre Public Health Institute, Polígono de Landaben C/F, Pamplona 31012, Spain.
K-T KhawUniversity of Cambridge School of Clinical Medicine, Robinson Way, Cambridge CB2 0SR, UK.
N WarehamMRC Epidemiology Unit, University of Cambridge, 184 Hills Road, Cambridge CB2 8PQ, UK.
R C TravisCancer Epidemiology Unit, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.
Y LuDepartment of Epidemiology & Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
M A MerrittDepartment of Epidemiology & Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
A Trichopoulou1] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece [2] Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece.
V BenetouDepartment of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75M. Asias Street, Goudi GR-115 27, Athens, Greece.
D Trichopoulos1] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece [2] Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece [3] Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
C SaievaMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Ponte Nuovo, Via delle Oblate n.2, Florence 50141, Italy.
S SieriEpidemiology and Prevention Unit, Fondazione IRCSS Istituto Nazionale dei Tumori, Via Venezian, 1, Milano 20133, Italy.
R TuminoCancer Registry and Histopathology Unit, "Civic-M.P.Arezzo" Hospital, Via Civile, Ragusa 97100, Italy.
C Sacerdote1] Unit of Cancer Epidemiology, AO Citta' della Salute e della Scienza-University of Turin and Center for Cancer Prevention (CPO-Piemonte), Via Santena 7, 10126 Turin, Italy [2] Human Genetics Foundation (HuGeF), Via Nizza 52, 10126 Turin, Italy.
R GalassoUnit of Clinical Epidemiology, Biostatistics and Cancer Registry IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy.
H B Bueno-de-Mesquita1] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands [2] Department of Gastroenterology and Hepatology, University Medical Centre, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands [3] The School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
E WirfältDepartment of Clinical Sciences, Nutrition Epidemiology, Lund University, Box 117, Malmö 205 02, Sweden.
U EricsonDepartment of Clinical Sciences, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Clinical Research Centre, Box 117, Malmö 205 02, Sweden.
A Idahl1] Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, 1A, 9 tr, Kirurgcentrum, 952, Umeå 901 85, Sweden [2] Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, 1A, 9 tr, Kirurgcentrum, 952, Umeå 901 85, Sweden.
N OhlsonDepartament of Medical Biosciences, Pathology, Umeå University, 1A, 9 tr, Kirurgcentrum, 952, Umeå 901 85, Sweden.
G SkeieDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, Breivika N-9037, Norway.
I T GramDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, Breivika N-9037, Norway.
E Weiderpass1] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Breivika N-9037, Norway [2] Department of Research, Cancer Registry of Norway, P.O. box 5313 Majorstuen Oslo, N-0304 Oslo, Norway [3] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Box 281, Stockholm 171 77, Sweden [4] Public Health Research Center, Public Health Association, Topeliusgatan 20 (PB 211), 00250 Helsinki, Finland.
N C Onland-MoretJulius Center for Health Sciences and Primary Care, University Medical Center, Huispost Str. 6.131, 3508GA Utrecht, The Netherlands.
E RiboliDepartment of Epidemiology & Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
E J DuellUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Avda Gran Via Barcelona 199-203, 08908L'Hospitalet de Llobregat, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESCentre International de Recherche sur le Cancer · FRImperial College London · GBInstitut d'Investigació Biomédica de Bellvitge · ESUiT The Arctic University of Norway · NODanish Cancer Society · DKGerman Cancer Research Center · DEHellenic Health Foundation · GRLund University · SEPiedmont Reference Center for Epidemiology and Cancer Prevention · ITUmeå University · SEAarhus University · DKAzienda Usl 8 Arezzo · ITCancer Council Victoria · AUCentre de recherche en Epidémiologie et Santé des Populations · FRFondazione IRCCS Istituto Nazionale dei Tumori · ITGerman Institute of Human Nutrition · DEInserm · FRIstituti di Ricovero e Cura a Carattere Scientifico · ITMRC Epidemiology Unit · GB

Funding

Cancer Research UK 14136Cancer Research UK 16491Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_U106179471Medical Research Council MC_UU_12015/1World Health Organization 001
6 · The paper itself

Abstract

backgroundThree prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.

methodsCox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.

resultsNo associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).

conclusionsDietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.

Indexed as

AcrylamideCohort StudiesDietEatingEndometrial NeoplasmsFemaleHumansMiddle AgedNutritional StatusProspective StudiesRiskRisk FactorsSmokingAcrylamide

Identifiers

PMID24937665
PMCPMC4150262
OpenAlexW2021827102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.