ArticlePloS one2014
Lifespan psychomotor behaviour profiles of multigenerational prenatal stress and artificial food dye effects in rats.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Potential impacts of synthetic food dyes on activity and attention in children: a review of the human and animal evidence.Environmental health : a global access science source · 2022Pooled it
- Food additive mixtures in French children and adults: the nationally representative Esteban study.Scientific reports · 2025Article
- Biochemical Alterations and Motor Dysfunctions in Corpus Striatum of Rats Brain Exposed to Azo Dyes.Toxicology research · 2024Article
- Dietary Exposure to United States Food and Drug Administration-Approved Synthetic Food Colors in Children, Pregnant Women, and Women of Childbearing Age Living in the United States.International journal of environmental research and public health · 2022Article
- Article
- Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk.Aging · 2020Article
- Ancestral Stress Alters Lifetime Mental Health Trajectories and Cortical Neuromorphology via Epigenetic Regulation.Scientific reports · 2019Article
- Prenatal two-hit stress affects maternal and offspring pregnancy outcomes and uterine gene expression in rats: match or mismatch?Biology of reproduction · 2019Article
- Prenatal noise stress impairs HPA axis and cognitive performance in mice.Scientific reports · 2017Article
- The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour.Scientific reports · 2017Article
- Ancestral Exposure to Stress Generates New Behavioral Traits and a Functional Hemispheric Dominance Shift.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Corticosterone response to gestational stress and postpartum memory function in mice.PloS one · 2017Article
- Evidence for Ancestral Programming of Resilience in a Two-Hit Stress Model.Frontiers in behavioral neuroscience · 2017Article
- Stress transgenerationally programs metabolic pathways linked to altered mental health.Cellular and molecular life sciences : CMLS · 2016Article
- Environmental Intervention as a Therapy for Adverse Programming by Ancestral Stress.Scientific reports · 2016Article
- Allostatic Load and Preterm Birth.International journal of molecular sciences · 2015Review
- Animal Models in Cardiovascular Research: Hypertension and Atherosclerosis.BioMed research international · 2015Review
- Vitamin D supplementation positively affects activity but impairs stimulus response behavior in an age and sex specific manner in C57BL/6 mice.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The consumption of artificial food dye (AFD) during childhood and adolescence has been linked to behavioural changes, such as hyperactivity. It is possible that the vulnerability to AFDs is modified by prenatal stress. Common consequences of prenatal stress include hyperactivity, thus potentially leading to synergistic actions with AFDs. Here, we investigated the compounding effect of multigenerational prenatal stress (MPS) and AFD consumption on the development of hyperactivity and anxiety-related behaviours across the lifespan in male rats. MPS treatment involved a family history of four consecutive generations of prenatal stress (F4 generation). AFD treatment included a 4%-concentration of FD&C Red 40, FD&C Yellow 5, FD&C Yellow 6, and FD&C Blue 1 in the drinking water from postnatal days 22 to 50 to resemble juvenile and adolescent dietary exposure. Using several exploration tasks, animals were tested in motor activity and anxiety-like behaviours from adolescence to 13 months of age. MPS resulted in hyperactivity both early (50 days) and later in life (13 months), with normalized activity patterns at reproductive age. AFD consumption resulted in hyperactivity during consumption, which subsided following termination of treatment. Notably, both MPS and AFD promoted risk-taking behaviour in young adults (3 months). There were few synergistic effects between MPS and AFD in this study. The findings suggest that AFDs exert the most noticeable effects at the time of exposure. MPS, however, results in a characteristic lifespan profile of behavioural changes, indicating that development and aging represent particularly vulnerable periods in life during which a family history of prenatal stress may precipitate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.