ArticleRadiology2014
Multimodal MR imaging of brain iron in attention deficit hyperactivity disorder: a noninvasive biomarker that responds to psychostimulant treatment?
Article in Radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Serum ferritin in children with Attention Deficit Hyperactivity Disorder (ADHD): A systematic review and meta-analysis.PloS one · 2026Pooled it
- Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damage.Frontiers in pharmacology · 2022Pooled it
- Peripheral iron levels in children with attention-deficit hyperactivity disorder: a systematic review and meta-analysis.Scientific reports · 2018Pooled it
- Iron Status in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.PloS one · 2017Pooled it
- Effects of iron supplementation of low-birth-weight infants on cognition and behavior at 7 years: a randomized controlled trial.Pediatric research · 2018Trial
- Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Impact of Serum Ferritin on the Pathophysiology of Attention-Deficit/Hyperactivity Disorder: What Is the Evidence?Cureus · 2026Review
- IronDeficiency Across Neurodevelopmental Disorders: Comparative Insights from ADHD and Autism Spectrum Disorder.Children (Basel, Switzerland) · 2026Review
- Iron dyshomeostasis in neuropsychiatric disorders.Frontiers in psychiatry · 2026Review
- Quantitative susceptibility mapping of brain iron in adult ADHD.Frontiers in psychiatry · 2026Article
- Brain iron deficiency in children with attention deficit hyperactivity disorder using iterAtive magnetic suscePtibility sources sepARaTion (APART-QSM).Quantitative imaging in medicine and surgery · 2025Article
- Iron Deficiency and Sleep/Wake Behaviors: A Scoping Review of Clinical Practice Guidelines-How to Overcome the Current Conundrum?Nutrients · 2024Article
- Comparison of three magnetic resonance imaging measures of brain iron in healthy and cocaine use disorder participants.NMR in biomedicine · 2024Article
- Multivariate and regional age-related change in basal ganglia iron in neonates.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Association among attention-deficit hyperactivity disorder, restless legs syndrome, and peripheral iron status: a two-sample Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Developmental coupling of brain iron and intrinsic activity in infants during the first 150 days.Developmental cognitive neuroscience · 2023Article
- Brain Iron Homeostasis and Mental Disorders.Antioxidants (Basel, Switzerland) · 2023Review
- Can biomarkers be used to diagnose attention deficit hyperactivity disorder?Frontiers in psychiatry · 2023Review
- Reduced basal ganglia tissue-iron concentration in school-age children with attention-deficit/hyperactivity disorder is localized to limbic circuitry.Experimental brain research · 2022Article
- Serum ferritin levels in children with attention deficit hyperactivity disorder and tic disorder.World journal of clinical cases · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo comprehensively assess brain iron levels in typically developing control subjects and patients with attention deficit hyperactivity disorder (ADHD) when psychostimulant medication history is accounted for. MATERIALS AND
methodsThis prospective study was approved by the institutional review board, and informed consent was obtained. Brain iron was indexed noninvasively by using magnetic resonance (MR) imaging relaxation rates (R2, R2*, R2') and magnetic field correlation (MFC) in the globus pallidus, putamen, caudate nucleus, and thalamus for 22 patients with ADHD (12 medication-naïve patients and 10 with a history of psychostimulant treatment) and 27 control subjects (age range, 8-18 years). Serum iron measures were also collected. Subgroup differences were analyzed with data-appropriate omnibus tests followed by post hoc pairwise comparisons; false discovery rate correction was conducted to control for multiple comparisons.
resultsMedication-naïve ADHD patients had significantly lower striatal and thalamic MFC indexes of brain iron than did control subjects (putamen, P = .012; caudate nucleus, P = .008; thalamus, P = .012) and psychostimulant-medicated ADHD patients (putamen, P = .006; caudate nucleus, P = .010; thalamus, P = .021). Conversely, the MFC indexes in medicated patients were comparable to those in control subjects. No significant differences were detected with R2, R2*, R2', or serum measures.
conclusionLower MFC indexes of striatal and thalamic brain iron in medication-naïve ADHD patients and lack of differences in psychostimulant-medicated patients suggest that MFC indexes of brain iron may represent a noninvasive diagnostic biomarker that responds to psychostimulant treatment.
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