ArticleInternational journal of radiation biology2014
Cellular response of the rat brain to single doses of (137)Cs γ rays does not predict its response to prolonged 'biologically equivalent' fractionated doses.
Article in International journal of radiation biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Gamma radiation improves AD pathogenesis in APP/PS1 mouse model by potentiating insulin sensitivity.Heliyon · 2020Article
- Minimal difference between fractionated and single-fraction exposure in a murine model of radiation necrosis.Radiation oncology (London, England) · 2019Article
- Chronic disturbance in the thalamus following cranial irradiation to the developing mouse brain.Scientific reports · 2019Article
- Risks of cognitive detriments after low dose heavy ion and proton exposures.International journal of radiation biology · 2019Review
- White Matter is the Predilection Site of Late-Delayed Radiation-Induced Brain Injury in Non-Human Primates.Radiation research · 2019Article
- Upregulated epithelial junction expression represents a novel parameter of the epithelial radiation response to fractionated irradiation in oral mucosa.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018Article
- Modeling Reveals the Dependence of Hippocampal Neurogenesis Radiosensitivity on Age and Strain of Rats.Frontiers in neuroscience · 2018Article
- The impact of high and low dose ionising radiation on the central nervous system.Redox biology · 2016Review
- Changes in Imaging and Cognition in Juvenile Rats After Whole-Brain Irradiation.International journal of radiation oncology, biology, physics · 2016Article
- Analysis of radiation therapy in a model of triple-negative breast cancer brain metastasis.Clinical & experimental metastasis · 2015Article
- Introduction to Michael E. Robbins memorial issue.International journal of radiation biology · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo determine if the brain's response to single doses predicts its response to 'biologically equivalent' fractionated doses.
methodsYoung adult male Fischer 344 rats were whole-brain irradiated with either single 11, 14, or 16.5 Gy doses of (137)Cs γ rays or their 'biologically equivalent' 20, 30, or 40 Gy fractionated doses (fWBI) delivered in 5 Gy fractions, twice/week for 2, 3, or 4 weeks, respectively. At 2 months post-irradiation, cellular markers of inflammation (total, activated, and newborn microglia) and neurogenesis (newborn neurons) were measured in 40 μm sections of the dentate gyrus (DG).
resultsAlthough the total number of microglia in the DG/hilus was not significantly different (p > 0.7) in unirradiated, single dose, and fWBI rats, single doses produced a significant (p < 0.003) increase in the percent-activated microglia; fWBI did not (p > 0.1). Additionally, single doses produced a significant (p < 0.002) dose-dependent increase in surviving newborn microglia; fWBI did not (p < 0.8). Although total proliferation in the DG was reduced equally by single and fWBI doses, single doses produced a significant dose-dependent (p < 0.02) decrease in surviving newborn neurons; fWBI did not (p > 0.6).
conclusionsThese data demonstrate that the rat brain's cellular response to single doses often does not predict its cellular response to 'biologically equivalent' fWBI doses.
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