ArticleJournal of the American Chemical Society2014
Photoactivatable glycopolymers for the proteome-wide identification of fucose-α(1-2)-galactose binding proteins.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Synthesis and Characterization of α,ω-End Orthogonally Functionalizable Glycopolymers from Native Glycans.Polymer chemistry · 2024Article
- Protein oxidation of fucose environments (POFE) reveals fucose-protein interactions.Chemical science · 2024Article
- Stereoselective synthesis of photoactivatable Man(β1,4)GlcNAc-based bioorthogonal probes.Tetrahedron letters · 2023Article
- The Association of the Polymorphisms in theInternational journal of molecular sciences · 2023Article
- (Glycan Binding) Activity-Based Protein Profiling in Cells Enabled by Mass Spectrometry-Based Proteomics.Israel journal of chemistry · 2023Article
- Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport.Journal of the American Chemical Society · 2022Article
- Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling.International journal of molecular sciences · 2022Article
- Tools for mammalian glycoscience research.Cell · 2022Review
- Seeing the forest through the trees: characterizing the glycoproteome.Trends in biochemical sciences · 2022Review
- All-optical monitoring of excitation-secretion coupling demonstrates that SV2A functions downstream of evoked CaThe Journal of physiology · 2022Article
- Synthesis of aryl azide chain-end functionalizedRSC advances · 2020Article
- Photocrosslinking probes for capture of carbohydrate interactions.Current opinion in chemical biology · 2019Review
- Post-traumatic stress disorder affects fucose-α(1-2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy.Translational psychiatry · 2019Article
- Synthesis of water-soluble fluorescent polymeric glycoconjugate for the detection of cholera toxin.Designed monomers and polymers · 2019Article
- Alternative splice variants of DCLK1 mark cancer stem cells, promote self-renewal and drug-resistance, and can be targeted to inhibit tumorigenesis in kidney cancer.International journal of cancer · 2018Article
- Tools for Studying Glycans: Recent Advances in Chemoenzymatic Glycan Labeling.ACS chemical biology · 2017Review
- Gold nanoparticle-based multivalent carbohydrate probes: selective photoaffinity labeling of carbohydrate-binding proteins.Chemical science · 2016Article
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Authors and funding
3 authors.
Funding
Abstract
Although fucose-α(1-2)-galactose (Fucα(1-2)Gal)-containing glycans have been implicated in cognitive processes such as learning and memory, their precise molecular mechanisms are poorly understood. Here we employed the use of multivalent glycopolymers to enable the first proteome-wide identification of weak affinity, low abundance Fucα(1-2)Gal glycan-binding proteins (GBPs). Biotin-terminated glycopolymers containing photoactivatable cross-linking groups were designed to capture and enrich GBPs from rat brain lysates. Candidate proteins were tested for their ability to bind Fucα(1-2)Gal, and the functional significance of the interaction was investigated for the synaptic vesicle protein SV2a using a knockout mouse system. The results suggest a role for SV2a-Fucα(1-2)Gal interactions in SV2a trafficking and synaptic vesicle recycling. More broadly, our studies outline a general chemical approach for the systems-level discovery of novel GBPs.
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