ArticlePloS one2014
Non melanoma skin cancer and subsequent cancer risk.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- All-cause mortality in patients with basal and squamous cell carcinoma: A systematic review and meta-analysis.Journal of the American Academy of Dermatology · 2018Pooled it
- Guidelines of care for the management of cutaneous squamous cell carcinoma.Journal of the American Academy of Dermatology · 2018Guideline
- Review
- Common skin cancers and their association with other non-cutaneous primary malignancies: a review of the literature.Medical oncology (Northwood, London, England) · 2024Review
- History of keratinocyte carcinoma and survival after a second primary malignancy: the Moffitt Cancer Center patient experience.Journal of cancer research and clinical oncology · 2023Article
- Economic burden of skin cancer treatment in the USA: an analysis of the Medical Expenditure Panel Survey Data, 2012-2018.Cancer causes & control : CCC · 2023Article
- Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort Study.Acta dermato-venereologica · 2023Article
- High-fidelity detection, subtyping, and localization of five skin neoplasms using supervised and semi-supervised learning.Journal of pathology informatics · 2023Article
- Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations.PLoS genetics · 2023Article
- Article
- Interventions After First Post-Transplant Cutaneous Squamous Cell Carcinoma: A Proposed Decision Framework.Transplant international : official journal of the European Society for Organ Transplantation · 2022Review
- Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma.Archives of dermatological research · 2021Article
- Investigating DNA methylation as a potential mediator between pigmentation genes, pigmentary traits and skin cancer.Pigment cell & melanoma research · 2021Article
- Sunscreen application technique amongst patients with a history of skin cancer.Archives of dermatological research · 2020Article
- Patient and physician factors associated with Oncotype DX and adjuvant chemotherapy utilization for breast cancer patients in New Hampshire, 2010-2016.BMC cancer · 2020Article
- Viruses in Skin Cancer (VIRUSCAN): Study Design and Baseline Characteristics of a Prospective Clinic-Based Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Food insecurity among adult cancer survivors in the United States.Journal of cancer survivorship : research and practice · 2019Article
- A panel of biomarkers for skin squamous cell carcinoma: various functional entities and differential responses to resveratrol.International journal of clinical and experimental pathology · 2019Article
- Risk factors for development of new skin neoplasms in patients with past history of skin cancer: A survival analysis.Scientific reports · 2018Article
- Red meat and processed meat intake and risk for cutaneous melanoma in white women and men: Two prospective cohort studies.Journal of the American Academy of Dermatology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introductionSeveral studies have shown an increased risk of cancer after non melanoma skin cancers (NMSC) but the individual risk factors underlying this risk have not been elucidated, especially in relation to sun exposure and skin sensitivity to sunlight. PURPOSE: The aim of this study was to examine the individual risk factors associated with the development of subsequent cancers after non melanoma skin cancer.
methodsParticipants in the population-based New Hampshire Skin Cancer Study provided detailed risk factor data, and subsequent cancers were identified via linkage with the state cancer registry. Deaths were identified via state and national death records. A Cox proportional hazard model was used to estimate risk of subsequent malignancies in NMSC patients versus controls and to assess the potential confounding effects of multiple risk factors on this risk.
resultsAmong 3584 participants, risk of a subsequent cancer (other than NMSC) was higher after basal cell carcinoma (BCC) (adjusted HR 1.40 [95% CI 1.15, 1.71]) than squamous cell carcinoma (SCC) (adjusted HR 1.18 [95% CI 0.95, 1.46]) compared to controls (adjusted for age, sex and current cigarette smoking). After SCC, risk was higher among those diagnosed before age 60 (HR 1.96 [95% CI 1.24, 3.12]). An over 3-fold risk of melanoma after SCC (HR 3.62; 95% CI 1.85, 7.11) and BCC (HR 3.28; 95% CI 1.66, 6.51) was observed, even after further adjustment for sun exposure-related factors and family history of skin cancer. In men, prostate cancer incidence was higher after BCC compared to controls (HR 1.64; 95% CI 1.10, 2.46).
conclusionsOur population-based study indicates an increased cancer risk after NMSC that cannot be fully explained by known cancer risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.