Evidence map›Paper›PMID 24937182›Full record

ArticleNature communications2014

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy.

Jingmei Li, Linda S Lindström, Jia N Foo, Sajjad Rafiq, Marjanka K Schmidt, Paul D P Pharoah, Kyriaki Michailidou, Joe Dennis, Manjeet K Bolla, Qin Wang and 93 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Identification of novel genetic markers of breast cancer survival.Journal of the National Cancer Institute · 2015
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Expression ofOncology letters · 2017
    Article
  7. Discriminatory power of common genetic variants in personalized breast cancer diagnosis.Proceedings of SPIE--the International Society for Optical Engineering · 2016
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

103 authors at 20 institutions in 16 countries.

Jingmei Li1] Human Genetics, Genome Institute of Singapore, 60 Biopolis Street 02-01, Singapore 138672, Singapore [2] Saw Swee Hock School of Public Health, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore [3].
Linda S Lindström1] Department of Surgery, University of California at San Francisco (UCSF), San Francisco, California 94143, USA [2] Department of Biosciences and Nutrition, Karolinska Institutet and University Hospital, SE-171 77 Stockholm, Sweden [3].
Jia N FooHuman Genetics, Genome Institute of Singapore, 60 Biopolis Street 02-01, Singapore 138672, Singapore.
Sajjad RafiqFaculty of Medicine, University of Southampton, University Hospital Southampton, Southampton SO16 6YD, UK.
Marjanka K Schmidt1] Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, The Netherlands [2] Division of Molecular Pathology, Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, The Netherlands.
Paul D P Pharoah1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Laura J Van 't VeerDivision of Molecular Pathology, Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, The Netherlands.
Sten CornelissenDivision of Molecular Pathology, Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, The Netherlands.
Emiel RutgersDepartment of Surgery, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Melissa C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, 5th floor, West Wing, Medical Building 181, Melbourne, Victoria 3010, Australia.
Carmel ApicellaCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia.
Gillian S DiteCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia.
John L Hopper1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia [2] Department of Health Science and Services, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
Peter A Fasching1] University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054 Erlangen, Germany [2] Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA.
Lothar HaeberleUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054 Erlangen, Germany.
Arif B EkiciInstitute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Schlossplatz 4, 91054 Erlangen, Germany.
Matthias W BeckmannUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054 Erlangen, Germany.
Carl BlomqvistDepartment of Oncology, University of Helsinki and Helsinki University Central Hospital, FI-00029 HUS Helsinki, Finland.
Taru A MuranenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FI-00029 Helsinki, Finland.
Kristiina AittomäkiDepartment of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FI-00029 Helsinki, Finland.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-17177, Sweden.
Sara MargolinDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm SE-17177, Sweden.
Arto Mannermaa1] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Yliopistonranta 1C, FI-70211 Kuopio, Finland [2] Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, FI-70211 Kuopio, Finland [3] Cancer Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
Veli-Matti Kosma1] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Yliopistonranta 1C, FI-70211 Kuopio, Finland [2] Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, FI-70211 Kuopio, Finland [3] Cancer Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
Jaana M Hartikainen1] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Yliopistonranta 1C, FI-70211 Kuopio, Finland [2] Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, FI-70211 Kuopio, Finland [3] Cancer Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
Vesa Kataja1] School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Yliopistonranta 1C, FI-70211 Kuopio, Finland [2] Cancer Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland [3] Jyväskylä Central Hospital, Keskussairaalantie 19, 40620 Jyväskylä, Finland.
Georgia Chenevix-TrenchDepartment of Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, Queensland 4006, Australia.
kConFab Investigators
Kelly-Anne Phillips1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia [2] Sir Peter MacCallum Department of Oncology, University of Melbourne, St Andrews Place East, East Melbourne, Victoria 3002, Australia.
Sue-Anne McLachlanDepartment of Oncology, St Vincent's Hospital Melbourne, 9 Princes Street, Fitzroy, Victoria 3065, Australia.
Diether Lambrechts1] Vesalius Research Center (VRC), VIB, Herestraat 49, 3000 Leuven, Belgium [2] Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Herestraat 49, 3000 Leuven, Belgium.
Bernard Thienpont1] Vesalius Research Center (VRC), VIB, Herestraat 49, 3000 Leuven, Belgium [2] Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Herestraat 49, 3000 Leuven, Belgium.
Ann SmeetsMultidisciplinary Breast Center, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
Hans WildiersMultidisciplinary Breast Center, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Dieter Flesch-Janys1] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany [2] Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany [3] Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Petra SeiboldDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Graham G Giles1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia [2] Cancer Epidemiology Centre, Cancer Council Victoria, 1 Rathdowne Street, Melbourne, Victoria 3053, Australia.
Laura Baglietto1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia [2] Cancer Epidemiology Centre, Cancer Council Victoria, 1 Rathdowne Street, Melbourne, Victoria 3053, Australia.
Gianluca Severi1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 1, 723 Swanston Street, Melbourne, Victoria 3010, Australia [2] Cancer Epidemiology Centre, Cancer Council Victoria, 1 Rathdowne Street, Melbourne, Victoria 3053, Australia.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 San Pablo Street, Los Angeles, California 90033, USA.
Brian E HendersonUniversity of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, Hawaii 96813, USA.
Fredrick SchumacherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 San Pablo Street, Los Angeles, California 90033, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, Hawaii 96813, USA.
Vessela Kristensen1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway [2] K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway [3] Department of Clinical Molecular Biology (EpiGen), Medical Division, Akershus University Hospital, Sykehusveien 25, 1478 Lørenskog, Norway.
Grethe I Grenaker Alnæs1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway [2] K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway.
Anne-Lise Borresen-Dale1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway [2] K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway.
Silje Nord1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen 70, N-0310 Oslo, Norway [2] K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, Aapistie 5A, FI-90220 Oulu, Finland.
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, Aapistie 5A, FI-90220 Oulu, Finland.
Arja Jukkola-VuorinenLaboratory of Oncology, Oulu University Hospital, University of Oulu, Kajaanintie 50, FI-90220 Oulu, Finland.
Mervi GripLaboratory of Oncology, Oulu University Hospital, University of Oulu, Kajaanintie 50, FI-90220 Oulu, Finland.
Irene L Andrulis1] Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1 × 5 [2] Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.
Julia A Knight1] Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1 × 5 [2] Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada M5T 3M7.
Gord GlendonOntario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1 × 5.
Sandrine TchatchouResearch, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1 × 5.
Peter Devilee1] Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands [2] Department of Pathology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
Robert TollenaarDepartment of Surgical Oncology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
Caroline SeynaeveDepartment of Medical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075EA Rotterdam, The Netherlands.
Maartje HooningDepartment of Medical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075EA Rotterdam, The Netherlands.
Mieke KriegeDepartment of Medical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075EA Rotterdam, The Netherlands.
Antoinette HollestelleDepartment of Medical Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075EA Rotterdam, The Netherlands.
Ans van den OuwelandDepartment of Clinical Genetics, Erasmus University Medical Center, Groene Hilledijk 301, 3075EA Rotterdam, The Netherlands.
Yi LiHuman Genetics, Genome Institute of Singapore, 60 Biopolis Street 02-01, Singapore 138672, Singapore.
Ute HamannMolecular Genetics of Breast Cancer, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Diana Torres1] Molecular Genetics of Breast Cancer, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany [2] Institute of Human Genetics, Pontificia University Javeriana, Carrera 7, Bogotá 11001000, Colombia.
Hans U UlmerFrauenklinik der Stadtklinik Baden-Baden, D-7570 Baden-Baden, Germany.
Thomas RüdigerInstitute of Pathology, Städtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133 Karlsruhe, Germany.
Chen-Yang Shen1] Institute of Biomedical Sciences, Academia Sinica, Academia Road Nankang, Taipei 115, Taiwan [2] College of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan.
Chia-Ni HsiungInstitute of Biomedical Sciences, Academia Sinica, Academia Road Nankang, Taipei 115, Taiwan.
Pei-Ei WuTaiwan Biobank, Academia Sinica, Academia Road Nankang, Taipei 115, Taiwan.
Shou-Tung ChenDepartment of Surgery, Changhua Christian Hospital, No. 135, Nanhsiao Street, Changhua 500, Taiwan.
Soo Hwang Teo1] Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS 12/1A, Subang Jaya47500, Selangor, Malaysia [2] Breast Cancer Research Unit, Faculty of Medicine, University Malaya Cancer Research Institute, University Malaya, Lembah Pantai, 59100 Kuala Lumpur, Malaysia.
Nur Aishah Mohd TaibBreast Cancer Research Unit, Faculty of Medicine, University Malaya Cancer Research Institute, University Malaya, Lembah Pantai, 59100 Kuala Lumpur, Malaysia.
Cheng Har YipBreast Cancer Research Unit, Faculty of Medicine, University Malaya Cancer Research Institute, University Malaya, Lembah Pantai, 59100 Kuala Lumpur, Malaysia.
Gwo Fuang HoDepartment of Oncology, Faculty of Medicine, University Malaya, Lembah Pantai, 59100 Kuala Lumpur, Malaysia.
Keitaro MatsuoDepartment of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Hidemi ItoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden Chikusa-ku, Nagoya 464-8681, Aichi, Japan.
Hiroji IwataDepartment of Breast Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden Chikusa-ku, Nagoya 464-8681, Aichi, Japan.
Kazuo TajimaDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden Chikusa-ku, Nagoya 464-8681, Aichi, Japan.
Daehee Kang1] Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea [2] Department of Biomedical Sciences, Seoul National University Graduate School, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
Ji-Yeob ChoiDepartment of Biomedical Sciences, Seoul National University Graduate School, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
Sue K Park1] Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea [2] Department of Biomedical Sciences, Seoul National University Graduate School, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
Keun-Young YooSeoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea.
Tom MaishmanFaculty of Medicine, University of Southampton, University Hospital Southampton, Southampton SO16 6YD, UK.
William J TapperFaculty of Medicine, University of Southampton, University Hospital Southampton, Southampton SO16 6YD, UK.
Alison DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK.
Robert LubenCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Judith BrownCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Chiea Chuen KhorHuman Genetics, Genome Institute of Singapore, 60 Biopolis Street 02-01, Singapore 138672, Singapore.
Diana M EcclesFaculty of Medicine, University of Southampton, University Hospital Southampton, Southampton SO16 6YD, UK.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FI-00029 Helsinki, Finland.
Douglas Easton1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK.
Keith HumphreysDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden.
Jianjun LiuHuman Genetics, Genome Institute of Singapore, 60 Biopolis Street 02-01, Singapore 138672, Singapore.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden.
University of Cambridge · GBThe University of Melbourne · AUGenome Institute of Singapore · SGGerman Cancer Research Center · DEKarolinska Institutet · SESeoul National University · KRErasmus MC Cancer Institute · NLFriedrich-Alexander-Universität Erlangen-Nürnberg · DEMount Sinai Hospital · CAOslo University Hospital · NOOulu University Hospital · FISouthampton General Hospital · GBThe Netherlands Cancer Institute · NLUniversity of Eastern Finland · FIUniversity of Helsinki · FIAichi Cancer Center · JPKU Leuven · BELeiden University Medical Center · NLUniversity of Hawaiʻi at Mānoa · USUniversity of Malaya · MY

Funding

GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098758 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2003 to 2010
$11.0M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Ovarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2M
A genome-wide association study for breast cancer in BRCA1 mutation carriersR01CA128978 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2008 to 2012
$4.8M
MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCERR01CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1993 to 2002
$4.5M
Fine-mapping of 8q24 and Loci Identified in Genome-Wide Studies for Breast & ColoR01CA132839 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAIMAN, CHRISTOPHER ALAN · 2008 to 2010
$2.0M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSU01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 1996 to 2000
$943k
Breast Cancer Now 2010NOVPR62Cancer Research UK 10124Cancer Research UK 15956Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 16565Cancer Research UK C12292/A11174Cancer Research UK C1275/A9896Cancer Research UK C1281/A12014Cancer Research UK C1287/A10118Cancer Research UK C1287/A10710Cancer Research UK C1287/A12014Cancer Research UK C490/A10124Cancer Research UK C5047/A10692Cancer Research UK C5047/A15007Cancer Research UK C5047/A8384CIHRNCI NIH HHS 1U19 CA148065NCI NIH HHS 1U19 CA148112NCI NIH HHS 1U19 CA148537NCI NIH HHS CA098758NCI NIH HHS CA128978NCI NIH HHS CA132839NCI NIH HHS CA54281NCI NIH HHS CA63464NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA132839NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA098758NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164920
6 · The paper itself

Abstract

Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

Indexed as

Breast NeoplasmsChromosomes, Human, Pair 2Drug TherapyFemaleGenetic MarkersHumansKaplan-Meier EstimateLinkage DisequilibriumPolymorphism, Single NucleotidePrognosisProportional Hazards ModelsWhite PeopleGenetic Markers

Identifiers

PMID24937182
PMCPMC4082638
OpenAlexW2098068164

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