Evidence map›Paper›PMID 24937071›Full record

ReviewNature chemical biology2014

How to control proteins with light in living systems.

Arnaud Gautier, Carole Gauron, Michel Volovitch, David Bensimon, Ludovic Jullien, Sophie Vriz

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed.

  1. Article
  2. Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Leaves to Measure Light Intensity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  11. Opsin-Free Activation of Bmp Receptors by a Femtosecond Laser.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arnaud Gautier1] École Normale Supérieure-Paris Sciences et Lettres (PSL) Research University, Department of Chemistry, Paris, France. [2] Sorbonne Universités, Université Pierre et Marie Curie (Université Paris 06), UMR 8640 PASTEUR, Paris, France. [3] CNRS, UMR 8640 PASTEUR, Paris, France.
Carole GauronCollege de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University, Paris, France.
Michel Volovitch1] College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University, Paris, France. [2] École Normale Supérieure, IBENS, CNRS UMR8197, INSERM U1024, PSL Research University, Paris, France.
David Bensimon1] École Normale Supérieure, IBENS, CNRS UMR8197, INSERM U1024, PSL Research University, Paris, France. [2] Laboratoire de Physique Statistique UMR CNRS-ENS 8550, PSL Research University, Paris, France. [3] Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California, USA.
Ludovic Jullien1] École Normale Supérieure-Paris Sciences et Lettres (PSL) Research University, Department of Chemistry, Paris, France. [2] Sorbonne Universités, Université Pierre et Marie Curie (Université Paris 06), UMR 8640 PASTEUR, Paris, France. [3] CNRS, UMR 8640 PASTEUR, Paris, France.
Sophie Vriz1] College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University, Paris, France. [2] Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The possibility offered by photocontrolling the activity of biomolecules in vivo while recording physiological parameters is opening up new opportunities for the study of physiological processes at the single-cell level in a living organism. For the last decade, such tools have been mainly used in neuroscience, and their application in freely moving animals has revolutionized this field. New photochemical approaches enable the control of various cellular processes by manipulating a wide range of protein functions in a noninvasive way and with unprecedented spatiotemporal resolution. We are at a pivotal moment where biologists can adapt these cutting-edge technologies to their system of study. This user-oriented review presents the state of the art and highlights technical issues to be resolved in the near future for wide and easy use of these powerful approaches.

Indexed as

AnimalsEukaryotic CellsGene ExpressionHumansLightMolecular ProbesOpsinsOptogeneticsPhotochemical ProcessesRhodopsins, MicrobialSingle-Cell AnalysisSpatio-Temporal AnalysisMolecular ProbesOpsinsRhodopsins, Microbial

Identifiers

PMID24937071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.