Trial reportAmerican journal of perinatology2015
The association of cord serum cytokines with neurodevelopmental outcomes.
Trial report in American journal of perinatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07211503 (Evaluating Correlation Ccrd Blood IL 6 and Neonatal Outcome and CTG Inflammatory Pattern), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Correlation Ccrd Blood IL 6 and Neonatal Outcome and CTG Inflammatory Pattern
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Relationship Between TNF-α and the Risk of Cerebral Palsy: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2022Pooled it
- Evaluation of Non-Faradaic Impedimetric Parameters for IL-8 Detection Using Gold Interdigitated Electrode-Based Biosensors: Towards Early Detection of Newborn Disability.Micromachines · 2025Article
- Serum cytokine profiles at near term-equivalent age and their association with neurodevelopmental outcomes in preterm infants: an exploratory study.Frontiers in pediatrics · 2025Article
- The Association Study Between Cytokines and the Risk for Cerebral Palsy.Mediators of inflammation · 2025Article
- Associations between the human immune system and gut microbiome with neurodevelopment in the first 5 years of life: A systematic scoping review.Developmental psychobiology · 2023Article
- Maternal Immune Activation Hypotheses for Human Neurodevelopment: Some Outstanding Questions.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Cytokine dysregulation persists in childhood post Neonatal Encephalopathy.BMC neurology · 2020Article
- An Integrative Review of Cytokine/Chemokine Predictors of Neurodevelopment in Preterm Infants.Biological research for nursing · 2019Review
- Cord Blood Haptoglobin, Cerebral Palsy and Death in Infants of Women at Risk for Preterm Birth: A Secondary Analysis of a Randomised Controlled Trial.EClinicalMedicine · 2019Article
- Epigenetic machine learning: utilizing DNA methylation patterns to predict spastic cerebral palsy.BMC bioinformatics · 2018Article
- Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure.Alcohol (Fayetteville, N.Y.) · 2018Article
- [Advances in genetic research of cerebral palsy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Review
- Urinary Levels of IL-1Mediators of inflammation · 2017Observational
- Circulating Inflammatory-Associated Proteins in the First Month of Life and Cognitive Impairment at Age 10 Years in Children Born Extremely Preterm.The Journal of pediatrics · 2017Article
- Plasma Tumor Necrosis Factor-alpha (TNF-α) Levels Correlate with Disease Severity in Spastic Diplegia, Triplegia, and Quadriplegia in Children with Cerebral Palsy.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis.Journal of ophthalmology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 18 institutions in 1 country.
Funding
Abstract
objectiveTo test whether elevated umbilical cord serum inflammatory cytokine levels predicted subsequent cerebral palsy (CP) or neurodevelopmental delay (NDD). STUDY
designNested case-control analysis within a clinical trial of antenatal magnesium sulfate (MgSO4) before anticipated preterm birth (PTB) for prevention of CP, with evaluation of surviving children at the age of 2. NDD was defined as a Bayley psychomotor developmental index (PDI) and/or mental developmental index (MDI) < 70. Controls, defined as surviving children without CP and with Bayley PDI and MDI ≥ 85, were matched by race and gestational age. Cord serum was analyzed for interleukin-8 (IL-8) interleukin-1 beta (IL-1β), and tumor necrosis factor-α (TNF-α) levels. Elevated cytokine levels were defined as ≥ 75th percentile in placebo-exposed controls. Analyses compared case/control cytokine levels, adjusting for MgSO4 exposure, gestational age, race/ethnicity, and sociodemographic differences.
resultsLogistic regression analysis with 339 cases and 276 controls showed that elevated IL-8 and IL-1β were more common in cord blood serum from infants with subsequent low MDI as compared with controls. After adjusting for additional confounders, the significant differences were no longer evident. Cytokine levels (IL-8, IL-1β, and TNF-α) were not elevated with CP or low PDI.
conclusionCord serum IL-8, IL-1β, and TNF-α levels in preterm infants are not associated with subsequent CP or NDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.