ArticlePLoS biology2014
Fusion of protein aggregates facilitates asymmetric damage segregation.
Article in PLoS biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- Balance between asymmetric allocation and repair of somatic damage in unicellular life forms as an ancient form of r/K selection.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unicellular life balances asymmetric allocation and repair of somatic damage representing the origin of r/K selection.bioRxiv : the preprint server for biology · 2023Article
- The cytoprotective sequestration activity of small heat shock proteins is evolutionarily conserved.The Journal of cell biology · 2022Article
- Long-term survival of Chlamydomonas reinhardtii during conditional senescence.Archives of microbiology · 2021Article
- Yeasts as Complementary Model Systems for the Study of the Pathological Repercussions of Enhanced Synphilin-1 Glycation and Oxidation.International journal of molecular sciences · 2021Article
- Vimentin protects differentiating stem cells from stress.Scientific reports · 2020Article
- TheeLife · 2020Article
- Article
- Ends and middle: Global force balance and septum location in fission yeast.The European physical journal. E, Soft matter · 2020Article
- Protein aggregation in bacteria.FEMS microbiology reviews · 2020Review
- Microbial ageing and longevity.Nature reviews. Microbiology · 2019Review
- Growth-driven displacement of protein aggregates along the cell length ensures partitioning to both daughter cells in Caulobacter crescentus.Molecular microbiology · 2019Article
- The fitness cost and benefit of phase-separated protein deposits.Molecular systems biology · 2019Article
- Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations.Nature communications · 2018Article
- Protein aggregates encode epigenetic memory of stressful encounters in individual Escherichia coli cells.PLoS biology · 2018Article
- IMiQ: a novel protein quality control compartment protecting mitochondrial functional integrity.Molecular biology of the cell · 2018Article
- Is Aggregate-Dependent Yeast Aging Fortuitous? A Model of Damage Segregation and Aggregate Dynamics.Biophysical journal · 2017Article
- Role of sHsps in organizing cytosolic protein aggregation and disaggregation.Cell stress & chaperones · 2017Review
- Article
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5 authors.
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Abstract
Asymmetric segregation of damaged proteins at cell division generates a cell that retains damage and a clean cell that supports population survival. In cells that divide asymmetrically, such as Saccharomyces cerevisiae, segregation of damaged proteins is achieved by retention and active transport. We have previously shown that in the symmetrically dividing Schizosaccharomyces pombe there is a transition between symmetric and asymmetric segregation of damaged proteins. Yet how this transition and generation of damage-free cells are achieved remained unknown. Here, by combining in vivo imaging of Hsp104-associated aggregates, a form of damage, with mathematical modeling, we find that fusion of protein aggregates facilitates asymmetric segregation. Our model predicts that, after stress, the increased number of aggregates fuse into a single large unit, which is inherited asymmetrically by one daughter cell, whereas the other one is born clean. We experimentally confirmed that fusion increases segregation asymmetry, for a range of stresses, and identified Hsp16 as a fusion factor. Our work shows that fusion of protein aggregates promotes the formation of damage-free cells. Fusion of cellular factors may represent a general mechanism for their asymmetric segregation at division.
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