ArticleAntimicrobial agents and chemotherapy2014
Decreasing Clostridium difficile infections by an antimicrobial stewardship program that reduces moxifloxacin use.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Interventions to improve antibiotic prescribing practices for hospital inpatients.The Cochrane database of systematic reviews · 2017Pooled it
- Impact of a multimodal antimicrobial stewardship intervention on fluoroquinolone usage for antimicrobial prophylaxis before urologic procedures in a Veterans Affairs outpatient clinic.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Review
- Strategies to preventInfection control and hospital epidemiology · 2023Article
- A Nonrestrictive Approach to Fluoroquinolone Stewardship at Two Community Hospitals.Open forum infectious diseases · 2022Article
- The protected antimicrobial process in a University Teaching Hospital: a qualitative interview study exploring the knowledge, attitudes, and experiences of healthcare professionals.International journal of clinical pharmacy · 2022Article
- Core Elements for Successful Implementation of Antimicrobial Stewardship Programs.Infection & chemotherapy · 2021Review
- How Far We've Come, How Far We Have to Go: a Review of Advances in Antimicrobial Stewardship in the Veterans Health Administration.Current treatment options in infectious diseases · 2020Article
- Impact of an antimicrobial stewardship program in the antimicrobial-resistant and prevalence of clostridioides difficile infection and amount of antimicrobial consumed in cancer patients.BMC research notes · 2020Article
- Evaluation of a successful fluoroquinolone restriction intervention among high-risk patients: A mixed-methods study.PloS one · 2020Article
- Restriction-free antimicrobial stewardship initiative targeting fluoroquinolone reduction across a regional health-system.Infection prevention in practice · 2019Article
- Inappropriate Use of Antimicrobials for Lower Respiratory Tract Infections in Elderly Patients: Patient- and Community-Related Implications and Possible Interventions.Drugs & aging · 2018Article
- Fluoroquinolone Restriction as an Effective Antimicrobial Stewardship Intervention.Current infectious disease reports · 2018Review
- [Antibiotic stewardship in a basic care hospital : A retrospective observational study].Der Anaesthesist · 2018Observational
- Effect of a Health Care System Respiratory Fluoroquinolone Restriction Program To Alter Utilization and Impact Rates of Clostridium difficile Infection.Antimicrobial agents and chemotherapy · 2017Article
- A stepwise introduction of a successful antimicrobial stewardship program. Experience from a tertiary care university hospital in Western, Saudi Arabia.Saudi medical journal · 2016Article
- Emergence and spread of moxifloxacin-resistantNew microbes and new infections · 2016Article
- A Review of Quality Measures for Assessing the Impact of Antimicrobial Stewardship Programs in Hospitals.Antibiotics (Basel, Switzerland) · 2016Review
- Optimizing Antibiotic Stewardship in Nursing Homes: A Narrative Review and Recommendations for Improvement.Drugs & aging · 2015Review
- Clostridium difficile ribotypes in Austria: a multicenter, hospital-based survey.Wiener klinische Wochenschrift · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium difficile infections (CDI) in hospitalized patients are known to be closely related to antibiotic exposure. Although several substances can cause CDI, the risk differs between individual agents. In Vienna and other eastern parts of Austria, CDI ribotype 027 is currently highly prevalent. This ribotype has the characteristic of intrinsic moxifloxacin resistance. Therefore, we hypothesized that moxifloxacin restriction can decrease the number of CDI cases in hospitalized patients. Our antibiotic stewardship (ABS) group applied an information campaign on CDI and formal restriction of moxifloxacin in Wilhelminenspital (Vienna, Austria), a 1,000- bed tertiary care hospital. The preintervention period (period 1) was January through May 2013, and the intervention period (period 2) was June through December 2013. We recorded the defined daily doses (DDD) of moxifloxacin and the number of CDI patients/month. Moxifloxacin use was reduced from a mean (±standard error of the mean [SEM]) of 1,038±109 DDD per month (period 1) to 42±10 DDD per month (period 2) (P=0.0045). Total antibiotic use was not affected. The mean (±SEM) numbers of CDI cases in period 1 were 59±3 per month and in period 2 were 32±3 per month (46% reduction; P=0.0044). Reducing moxifloxacin use in combination with providing structured information on CDI was associated with an immediate decrease in CDI rates in this large community teaching hospital.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.