Evidence map›Paper›PMID 24936469›Full record

ArticleStem cell reports2014

Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis.

Lu Chen, Ronald Coleman, Ronika Leang, Ha Tran, Alexandra Kopf, Craig M Walsh, Ilse Sears-Kraxberger, Oswald Steward, Wendy B Macklin, Jeanne F Loring and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
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  11. Article
  12. Stem Cell Therapies for Progressive Multiple Sclerosis.Frontiers in cell and developmental biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lu ChenDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, Irvine, CA 92697, USA.
Ronald ColemanCenter for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ronika LeangDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, Irvine, CA 92697, USA.
Ha TranCenter for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Alexandra KopfDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, Irvine, CA 92697, USA.
Craig M WalshDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, Irvine, CA 92697, USA.
Ilse Sears-KraxbergerReeve-Irvine Research Center, University of California, Irvine, Irvine, CA 92697, USA.
Oswald StewardReeve-Irvine Research Center, Departments of Anatomy & Neurobiology, Neurobiology & Behavior, and Neurosurgery, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Wendy B MacklinDepartment of Cell and Developmental Biology, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
Jeanne F LoringCenter for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Thomas E LaneDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, Irvine, CA 92697, USA.
University of California, Irvine · USScripps Research Institute · USUniversity of Colorado Anschutz Medical Campus · US

Funding

MYFLIN PROTEIN GENE EXPRESSIONR01NS025304 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MACKLIN, WENDY B · 1987 to 2013
$3.3M
Towards a therapy to regenerate corticospinal axonsR01NS073857 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI STEWARD, OSWALD · 2011 to 2015
$1.7M
NINDS NIH HHS R01 NS073857
6 · The paper itself

Abstract

Using a viral model of the demyelinating disease multiple sclerosis (MS), we show that intraspinal transplantation of human embryonic stem cell-derived neural precursor cells (hNPCs) results in sustained clinical recovery, although hNPCs were not detectable beyond day 8 posttransplantation. Improved motor skills were associated with a reduction in neuroinflammation, decreased demyelination, and enhanced remyelination. Evidence indicates that the reduced neuroinflammation is correlated with an increased number of CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) within the spinal cords. Coculture of hNPCs with activated T cells resulted in reduced T cell proliferation and increased Treg numbers. The hNPCs acted, in part, through secretion of TGF-β1 and TGF-β2. These findings indicate that the transient presence of hNPCs transplanted in an animal model of MS has powerful immunomodulatory effects and mediates recovery. Further investigation of the restorative effects of hNPC transplantation may aid in the development of clinically relevant MS treatments.

Indexed as

AnimalsCD4 AntigensCells, CulturedDisease Models, AnimalForkhead Transcription FactorsHumansImmunohistochemistryInterleukin-2 Receptor alpha SubunitMiceMultiple SclerosisNeural Stem CellsStem Cell TransplantationT-Lymphocytes, RegulatoryTransforming Growth Factor beta1Transforming Growth Factor beta2CD4 AntigensForkhead Transcription FactorsFOXP3 protein, humanInterleukin-2 Receptor alpha SubunitTransforming Growth Factor beta1Transforming Growth Factor beta2

Identifiers

PMID24936469
PMCPMC4050357
OpenAlexW2062521126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.