Evidence map›Paper›PMID 24936468›Full record

ArticleStem cell reports2014

Primitive neural stem cells in the adult mammalian brain give rise to GFAP-expressing neural stem cells.

Nadia Sachewsky, Rachel Leeder, Wenjun Xu, Keeley L Rose, Fenggang Yu, Derek van der Kooy, Cindi M Morshead

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
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  15. A mosaic world: puzzles revealed by adult neural stem cell heterogeneity.Wiley interdisciplinary reviews. Developmental biology · 2016
    Review
  16. Article
  17. Article
  18. In Vitro Models for Neurogenesis.Cold Spring Harbor perspectives in biology · 2016
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nadia SachewskyThe Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada ; Department of Surgery, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Rachel LeederThe Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada ; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Wenjun XuThe Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada ; Department of Surgery, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Keeley L RoseThe Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada ; Department of Surgery, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada ; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Fenggang YuThe Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada ; Department of Surgery, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Derek van der KooyThe Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada ; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Cindi M MorsheadThe Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada ; Department of Surgery, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada ; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
University of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult forebrain definitive neural stem cells (NSCs) comprise a subpopulation of GFAP-expressing subependymal cells that arise from embryonic fibroblast growth factor (FGF)-dependent NSCs that are first isolated from the developing brain at E8.5. Embryonic FGF-dependent NSCs are derived from leukemia inhibitory factor (LIF)-responsive, Oct4-expressing primitive NSCs (pNSCs) that are first isolated at E5.5. We report the presence of a rare population of pNCSs in the periventricular region of the adult forebrain. Adult-derived pNSCs (AdpNSCs) are GFAP(-), LIF-responsive stem cells that display pNSC properties, including Oct4 expression and the ability to integrate into the inner cell mass of blastocysts. AdpNSCs generate self-renewing, multipotent colonies that give rise to definitive GFAP(+) NSCs in vitro and repopulate the subependyma after the ablation of GFAP(+) NSCs in vivo. These data support the hypothesis that a rare population of pNSCs is present in the adult brain and is upstream of the GFAP(+) NSCs.

Indexed as

AnimalsBrainGlial Fibrillary Acidic ProteinMiceNerve Tissue ProteinsNeural Stem CellsNeuronsOctamer Transcription Factor-3Glial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseNerve Tissue ProteinsOctamer Transcription Factor-3Pou5f1 protein, mouse

Identifiers

PMID24936468
PMCPMC4050350
OpenAlexW2057671399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.