Evidence map›Paper›PMID 24936433›Full record

ArticleNeuroImage. Clinical2014

Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease.

Philip Benjamin, Andrew J Lawrence, Christian Lambert, Bhavini Patel, Ai Wern Chung, Andrew D MacKinnon, Robin G Morris, Thomas R Barrick, Hugh S Markus

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PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Philip BenjaminNeurosciences Research Centre, St George's University of London, UK.
Andrew J LawrenceDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Christian LambertNeurosciences Research Centre, St George's University of London, UK.
Bhavini PatelNeurosciences Research Centre, St George's University of London, UK.
Ai Wern ChungNeurosciences Research Centre, St George's University of London, UK.
Andrew D MacKinnonAtkinson Morley Regional Neuroscience Centre, St George's NHS Healthcare Trust, London, UK.
Robin G MorrisKing's College Institute of Psychiatry, London, UK.
Thomas R BarrickNeurosciences Research Centre, St George's University of London, UK.
Hugh S MarkusDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesLacunes are an important disease feature of cerebral small vessel disease (SVD) but their relationship to cognitive impairment is not fully understood. To investigate this we determined (1) the relationship between lacune count and total lacune volume with cognition, (2) the spatial distribution of lacunes and the cognitive impact of lacune location, and (3) the whole brain anatomical covariance associated with these strategically located regions of lacune damage.

methodsOne hundred and twenty one patients with symptomatic lacunar stroke and radiological leukoaraiosis were recruited and multimodal MRI and neuropsychological data acquired. Lacunes were mapped semi-automatically and their volume calculated. Lacune location was automatically determined by projection onto atlases, including an atlas which segments the thalamus based on its connectivity to the cortex. Lacune locations were correlated with neuropsychological results. Voxel based morphometry was used to create anatomical covariance maps for these 'strategic' regions.

resultsLacune number and lacune volume were positively associated with worse executive function (number p < 0.001; volume p < 0.001) and processing speed (number p < 0.001; volume p < 0.001). Thalamic lacunes, particularly those in regions with connectivity to the prefrontal cortex, were associated with impaired processing speed (Bonferroni corrected p = 0.016). Regions of associated anatomical covariance included the medial prefrontal, orbitofrontal, anterior insular cortex and the striatum.

conclusionLacunes are important predictors of cognitive impairment in SVD. We highlight the importance of spatial distribution, particularly of anteromedial thalamic lacunes which are associated with impaired information processing speed and may mediate cognitive impairment via disruption of connectivity to the prefrontal cortex.

Indexed as

AgedAged, 80 and overBrainBrain MappingCognition DisordersFemaleHumansImage Processing, Computer-AssistedLeukoaraiosisMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsStatistics as TopicStroke, LacunarCognitive ImpairmentLacunesSmall vessel disease

Identifiers

PMID24936433
PMCPMC4055894

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.