ArticleNeuroImage. Clinical2014
Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- The link between gut microbiota and multiple sclerosis from the perspective of barrier function.Frontiers in immunology · 2025Review
- Article
- Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- How does the brain age in individuals with multiple sclerosis? A systematic review.Frontiers in neurology · 2023Review
- Infantile status epilepticus disrupts myelin development.Neurobiology of disease · 2022Article
- Quantitative magnetization transfer imaging in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis.Brain communications · 2022Review
- Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients.Scientific reports · 2021Article
- Worse Physical Disability Is Associated With the Expression of PD-1 on Inflammatory T-Cells in Multiple Sclerosis Patients With Older Appearing Brains.Frontiers in neurology · 2021Article
- CHIT1 at Diagnosis Reflects Long-Term Multiple Sclerosis Disease Activity.Annals of neurology · 2020Article
- Advanced Magnetic Resonance Imaging Techniques in Management of Brain Metastases.Frontiers in oncology · 2019Review
- Glioblastoma (GBM) effects on quantitative MRI of contralateral normal appearing white matter.Journal of neuro-oncology · 2018Article
- Environmental enrichment reduces brain damage in hydrocephalic immature rats.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Edaravone reduces astrogliosis and apoptosis in young rats with kaolin-induced hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Aging of cerebral white matter.Ageing research reviews · 2017Review
- Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions.NeuroImage. Clinical · 2017Article
- Disability Progression in Multiple Sclerosis Is Affected by the Emergence of Comorbid Arterial Hypertension.Journal of clinical neurology (Seoul, Korea) · 2016Article
- Delineation of cortical pathology in multiple sclerosis using multi-surface magnetization transfer ratio imaging.NeuroImage. Clinical · 2016Article
- Advanced neuroimaging applied to veterans and service personnel with traumatic brain injury: state of the art and potential benefits.Brain imaging and behavior · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMultiple sclerosis (MS) is a heterogeneous disorder with a progressive course that is difficult to predict on a case-by-case basis. Natural history studies of MS have demonstrated that age influences clinical progression independent of disease duration.
objectiveTo determine whether age would be associated with greater CNS injury as detected by magnetization transfer MRI. MATERIALS AND
methodsForty MS patients were recruited from out-patient clinics into two groups stratified by age but with similar clinical disease duration as well as thirteen controls age-matched to the older MS group. Images were segmented by automated programs and blinded readers into normal appearing white matter (NAWM), normal appearing gray matter (NAGM), and white matter lesions (WMLs) and gray matter lesions (GMLs) in the MS groups. WML and GML were delineated on T2-weighted 3D fluid-attenuated inversion recovery (FLAIR) and T1 weighted MRI volumes. Mean magnetization transfer ratio (MTR), region volume, as well as MTR histogram skew and kurtosis were calculated for each region.
resultsAll MTR measures in NAGM and MTR histogram metrics in NAWM differed between MS subjects and controls, as expected and previously reported by several studies, but not between MS groups. However, MTR measures in the WML did significantly differ between the MS groups, in spite of no significant differences in lesion counts and volumes.
conclusionsDespite matching for clinical disease duration and recording no significant WML volume difference, we demonstrated strong MTR differences in WMLs between younger and older MS patients. These data suggest that aging-related processes modify the tissue response to inflammatory injury and its clinical outcome correlates in MS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.