ArticleNeuroImage. Clinical2014
Striatal disorders dissociate mechanisms of enhanced and impaired response selection - Evidence from cognitive neurophysiology and computational modelling.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Dose-Dependent Effects of Catecholaminergic Modulation on Interference Control: Role of Baseline GABA and Glx in Cortico-Subcortical Networks.Human brain mapping · 2025Trial
- Auricular Transcutaneous Vagus Nerve Stimulation Diminishes Alpha-Band-Related Inhibitory Gating Processes During Conflict Monitoring in Frontal Cortices.The international journal of neuropsychopharmacology · 2022Trial
- Dopamine Modulates the Efficiency of Sensory Evidence Accumulation During Perceptual Decision Making.The international journal of neuropsychopharmacology · 2018Trial
- GABA and Glx levels in cortico-subcortical networks predict catecholaminergic effects on response inhibition.Journal of psychopharmacology (Oxford, England) · 2025Article
- Gamma-Aminobutyric Acid and Glutamate Concentrations in the Striatum and Anterior Cingulate Cortex Not Found to Be Associated with Cognitive Flexibility.Brain sciences · 2023Article
- Transcutaneous Vagus Nerve Stimulation (tVNS) applications in cognitive aging: a review and commentary.Frontiers in aging neuroscience · 2023Review
- On the functional role of striatal and anterior cingulate GABA+ in stimulus-response binding.Human brain mapping · 2021Article
- A Computational Study of Executive Dysfunction in Amyotrophic Lateral Sclerosis.Journal of clinical medicine · 2020Article
- Predictive coding and adaptive behavior in patients with genetically determined cerebellar ataxia--A neurophysiology study.NeuroImage. Clinical · 2019Article
- Walking-Related Dual-Task Interference in Early-to-Middle-Stage Huntington's Disease: An Auditory Event Related Potential Study.Frontiers in psychology · 2017Article
- Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury.Neural regeneration research · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Paradoxically enhanced cognitive processes in neurological disorders provide vital clues to understanding neural function. However, what determines whether the neurological damage is impairing or enhancing is unclear. Here we use the performance of patients with two disorders of the striatum to dissociate mechanisms underlying cognitive enhancement and impairment resulting from damage to the same system. In a two-choice decision task, Huntington's disease patients were faster and less error prone than controls, yet a patient with the rare condition of benign hereditary chorea (BHC) was both slower and more error prone. EEG recordings confirmed significant differences in neural processing between the groups. Analysis of a computational model revealed that the common loss of connectivity between striatal neurons in BHC and Huntington's disease impairs response selection, but the increased sensitivity of NMDA receptors in Huntington's disease potentially enhances response selection. Crucially the model shows that there is a critical threshold for increased sensitivity: below that threshold, impaired response selection results. Our data and model thus predict that specific striatal malfunctions can contribute to either impaired or enhanced selection, and provide clues to solving the paradox of how Huntington's disease can lead to both impaired and enhanced cognitive processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.