ArticleNeuroImage. Clinical2014
Atypical sulcal anatomy in young children with autism spectrum disorder.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2021Pooled it
- Associations Between Teenage Motherhood, Perinatal Cortical Maturation, and Risk of Psychopathology in Children: The Mediating Role of Pregnancy Complications.Biological psychiatry global open science · 2026Article
- The superior temporal asymmetrical pit remains asymmetric in autism spectrum disorder.bioRxiv : the preprint server for biology · 2026Article
- Motifs of brain cortical folding from birth to adulthood.Nature communications · 2026Article
- Brain morphology network profiles in male and female youth with autism.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Linking changes in sulcal morphometry to cognitive development from childhood to adolescence.Communications biology · 2026Article
- Genetic insights on the mechanisms of human cortical folding.bioRxiv : the preprint server for biology · 2026Article
- Adaptive, social, and repetitive behaviors in children with autism spectrum disorder and comorbid amblyopia and/or strabismus.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2026Article
- Cortical Thickness and Curvature in Autism and ADHD: A Mega-Analysis.bioRxiv : the preprint server for biology · 2026Article
- Review
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Cortical Morphological Networks Differ Between Gyri and Sulci.Neuroscience bulletin · 2025Article
- Article
- Identification of rare cortical folding patterns using unsupervised deep learning.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Cortical Sulcal Abnormalities Revealed by Sulcal Morphometry in Patients with Chronic and Episodic Migraine.Journal of pain research · 2024Article
- A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients.bioRxiv : the preprint server for biology · 2023Article
- Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability.Brain structure & function · 2023Article
- Article
- The influence of biophysical parameters in a biomechanical model of cortical folding patterns.Scientific reports · 2021Article
- Sulcal Depth in the Medial Ventral Temporal Cortex Predicts the Location of a Place-Selective Region in Macaques, Children, and Adults.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder is associated with an altered early brain development. However, the specific cortical structure abnormalities underlying this disorder remain largely unknown. Nonetheless, atypical cortical folding provides lingering evidence of early disruptions in neurodevelopmental processes and identifying changes in the geometry of cortical sulci is of primary interest for characterizing these structural abnormalities in autism and their evolution over the first stages of brain development. Here, we applied state-of-the-art sulcus-based morphometry methods to a large highly-selective cohort of 73 young male children of age spanning from 18 to 108 months. Moreover, such large cohort was selected through extensive behavioral assessments and stringent inclusion criteria for the group of 59 children with autism. After manual labeling of 59 different sulci in each hemisphere, we computed multiple shape descriptors for each single sulcus element, hereby separating the folding measurement into distinct factors such as the length and depth of the sulcus. We demonstrated that the central, intraparietal and frontal medial sulci showed a significant and consistent pattern of abnormalities across our different geometrical indices. We also found that autistic and control children exhibited strikingly different relationships between age and structural changes in brain morphology. Lastly, the different measures of sulcus shapes were correlated with the CARS and ADOS scores that are specific to the autistic pathology and indices of symptom severity. Inherently, these structural abnormalities are confined to regions that are functionally relevant with respect to cognitive disorders in ASD. In contrast to those previously reported in adults, it is very unlikely that these abnormalities originate from general compensatory mechanisms unrelated to the primary pathology. Rather, they most probably reflect an early disruption on developmental trajectory that could be part of the primary pathology.
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