Evidence map›Paper›PMID 24936409›Full record

ArticleNeuroImage. Clinical2014

Error-related functional connectivity of the thalamus in cocaine dependence.

Sheng Zhang, Sien Hu, Sarah R Bednarski, Emily Erdman, Chiang-Shan R Li

Abstract read
In one paragraph

Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  9. Review
  10. Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  11. The thalamus in drug addiction: from rodents to humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
  19. Subcortical glutamate mediates the reduction of short-range functional connectivity with age in a developmental cohort.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sheng ZhangDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA.
Sien HuDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA.
Sarah R BednarskiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA.
Emily ErdmanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA.
Chiang-Shan R LiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA ; Inter-departmental Neuroscience Program, Yale University, New Haven, CT 06520, USA ; Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Funding

Cognitive control and cocaine dependence: thalamic noradrenergic processesR01DA023248 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2008 to 2018
$4.0M
Imaging Cognitive Control in Cocaine DependenceK02DA026990 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2009 to 2013
$639k
Thalamic Processes of Self Control in Cocaine DependenceR21DA026998 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2009 to 2010
$373k
NIDA NIH HHS K02 DA026990NIDA NIH HHS K02DA026990NIDA NIH HHS R01 DA023248NIDA NIH HHS R01DA023248NIDA NIH HHS R21 DA026998NIDA NIH HHS R21DA026998
6 · The paper itself

Abstract

Error processing is a critical component of cognitive control, an executive function that has been widely implicated in substance misuse. In previous studies we showed that error related activations of the thalamus predicted relapse to drug use in cocaine addicted individuals (Luo et al., 2013). Here, we investigated whether the error-related functional connectivity of the thalamus is altered in cocaine dependent patients (PCD, n = 54) as compared to demographically matched healthy individuals (HC, n = 54). The results of a generalized psychophysiological interaction analysis showed negative thalamic connectivity with the ventral medial prefrontal cortex (vmPFC), in the area of perigenual and subgenual anterior cingulate cortex, in HC but not PCD (p < 0.05, corrected, two-sample t test). This difference in functional connectivity was not observed for task-residual signals, suggesting that it is specific to task-related processes during cognitive control. Further, the thalamic-vmPFC connectivity is positively correlated with the amount of cocaine use in the prior month for female but not for male PCD. These findings add to recent literature and provide additional evidence for circuit-level biomarkers of cocaine dependence.

Indexed as

CognitionDecision MakingCocaine-Related DisordersConnectomeExecutive FunctionFemaleHumansMaleNerve NetNeural PathwaysReaction TimeReproducibility of ResultsSensitivity and SpecificitySex CharacteristicsThalamusCocaineCognitive controlfMRIPPIThalamusvmPFC

Identifiers

PMID24936409
PMCPMC4053644

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.