ArticleSpringerPlus2014
Multivariate statistical models of metabolomic data reveals different metabolite distribution patterns in isonitrosoacetophenone-elicited Nicotiana tabacum and Sorghum bicolor cells.
Article in SpringerPlus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
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- OPLS-Based Multiclass Classification and Data-Driven Interclass Relationship Discovery.Journal of chemical information and modeling · 2025Article
- Evidence on the inhibitory effect of Brassica plants against Acinetobacter baumannii lipases: phytochemical analysis, in vitro, and molecular docking studies.BMC complementary medicine and therapies · 2024Article
- Flavoromics Approach in Critical Aroma Compounds Exploration of Peach: Correlation to Origin Based on OAV Combined with Chemometrics.Foods (Basel, Switzerland) · 2023Article
- Comparative Analysis of Untargeted Metabolomics in Tolerant and Sensitive Genotypes of Common Bean (Metabolites · 2022Article
- Practical Considerations in Method Development for Gas Chromatography-Based Metabolomic Profiling.Advances in experimental medicine and biology · 2021Article
- Lipopolysaccharides trigger synthesis of the allelochemical sorgoleone in cell cultures ofPlant signaling & behavior · 2020Article
- Tibouchina granulosa (Vell.) Cogn (Melastomataceae) as source of endophytic fungi: isolation, identification, and antiprotozoal activity of metabolites from Phyllosticta capitalensis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Adaptive defence-related changes in the metabolome of Sorghum bicolor cells in response to lipopolysaccharides of the pathogen Burkholderia andropogonis.Scientific reports · 2020Article
- Mass spectrometry-based metabolomics approach in the isolation of bioactive natural products.Scientific reports · 2020Article
- Recent metabolomics and gene editing approaches for synthesis of microbial secondary metabolites for drug discovery and development.World journal of microbiology & biotechnology · 2019Review
- Metabolic responses to arbuscular mycorrhizal fungi are shifted in roots of contrasting soybean genotypes.Mycorrhiza · 2019Article
- Metabolite characterization of different palm date varieties and the correlation with their NO inhibitory activity, texture and sweetness.Journal of food science and technology · 2018Article
- Iterative cycle of widely targeted metabolic profiling for the improvement of 1-butanol titer and productivity inBiotechnology for biofuels · 2018Article
- A Metabolomics-Guided Exploration of the Phytochemical Constituents of Vernonia fastigiata with the Aid of Pressurized Hot Water Extraction and Liquid Chromatography-Mass Spectrometry.Molecules (Basel, Switzerland) · 2017Article
- Compositional analyses of diverse phytochemicals and polar metabolites from different-colored potato (Food science and biotechnology · 2017Article
- Metabolomics and Integrative Omics for the Development of Thai Traditional Medicine.Frontiers in pharmacology · 2017Review
- Transcriptome and Multivariable Data Analysis of Corynebacterium glutamicum under Different Dissolved Oxygen Conditions in Bioreactors.PloS one · 2016Article
- Stimulatory Effects of Acibenzolar-Frontiers in plant science · 2016Article
- Preparation of Mitochondrial Enriched Fractions for Metabolic Analysis in Drosophila.Journal of visualized experiments : JoVE · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isonitrosoacetophenone (INAP, 2-keto-2-phenyl-acetaldoxime) is a novel inducer of plant defense. Oxime functional groups are rare in natural products, but can serve as substrates depending on existing secondary pathways. Changes in the metabolomes of sorghum and tobacco cells treated with INAP were investigated and chemometric tools and multivariate statistical analysis were used to investigate the changes in metabolite distribution patterns resulting from INAP elicitation. Liquid chromatography combined with mass spectrometry (UHPLC-MS) supplied unique chemical fingerprints that were generated in response to specific metabolomic events. Principal component analysis (PCA) together with hierarchical cluster analysis (HCA) and Metabolic Trees were used for data visualization. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) and shared and unique structure (SUS) plots were exploited in parallel to reveal the changes in the metabolomes. PCA indicated that the cells responded differentially to INAP through changes in the metabolite profiles. Furthermore, HCA and Metabolic Trees showed that INAP induced metabolic perturbations in both cell lines and that homeostasis was re-established over time. OPLS-DA-based shared and unique structure (SUS) plots confirmed the results and revealed differences in the metabolites distribution patterns between tobacco and sorghum cells. Chemometric analyses of metabolomic data offers insight into changes in metabolism in response to chemical elicitation. Although similar, the response in sorghum cells was found to be more consistent and well-coordinated when compared to tobacco cells, indicative of the differences in secondary metabolism between cyanogenic and non-cyanogenic plants for oxime metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.