ArticleCirculation research2014
Embryonic stem cell-derived cardiac myocytes are not ready for human trials.
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Article in Circulation research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed.
- Advances in MicroRNA-Based Therapies for Cardiac Repair: Emerging Strategies for Treating Myocardial Infarction.Molecular and cellular biochemistry · 2026Review
- Three-dimensional spheroid models for cardiovascular biology and pathology.Mechanobiology in medicine · 2025Review
- Targeted delivery of engineered adipose-derived stem cell secretome to promote cardiac repair after myocardial infarction.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Cardiac commitment driven by MyoD expression in pericardial stem cells.Frontiers in cell and developmental biology · 2024Article
- Harnessing developmental cues for cardiomyocyte production.Development (Cambridge, England) · 2023Review
- Effect of CDM3 on co-culture of human-induced pluripotent stem cells with Matrigel-covered polycaprolactone to prepare cardiac patches.In vitro cellular & developmental biology. Animal · 2023Article
- Large animal models for cardiac remuscularization studies: A methodological review.Frontiers in cardiovascular medicine · 2023Review
- Cell-Based and Selected Cell-Free Therapies for Myocardial Infarction: How Do They Compare to the Current Treatment Options?International journal of molecular sciences · 2022Review
- Mesenchymal stem cell-derived extracellular vesicles for cell-free therapy of ocular diseases.Extracellular vesicles and circulating nucleic acids · 2022Review
- Layer-By-Layer Fabrication of Thicker and Larger Human Cardiac Muscle Patches for Cardiac Repair in Mice.Frontiers in cardiovascular medicine · 2021Article
- A realistic appraisal of the use of embryonic stem cell-based therapies for cardiac repair.European heart journal · 2020Article
- Cardiac Regeneration with Human Pluripotent Stem Cell-Derived Cardiomyocytes.Korean circulation journal · 2018Review
- New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications.Circulation research · 2018Review
- Pluripotent Stem Cell-Derived Cardiomyocytes as a Platform for Cell Therapy Applications: Progress and Hurdles for Clinical Translation.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Review
- Regenerative medicine in cardiothoracic surgery: do the benefits outweigh the risks?Journal of thoracic disease · 2018Article
- Induced pluripotent stem cells as a biopharmaceutical factory for extracellular vesicles.European heart journal · 2018Article
- Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells.Nature biomedical engineering · 2018Article
- Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine.Circulation · 2018Article
- Electrical Stimulation Enhances Cardiac Differentiation of Human Induced Pluripotent Stem Cells for Myocardial Infarction Therapy.Antioxidants & redox signaling · 2018Article
- Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids.Acta biomaterialia · 2017Article
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Authors and funding
5 authors.
Mark E AndersonFrom the Departments of Internal Medicine and Molecular Physiology & Biophysics, Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City (M.E.A); Cedars-Sinai Heart Institute, Los Angeles, CA (J.G.); Department of Physiology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.R.H.); INSERM UMR 910, Génétique médicale et génomique fonctionnelle, Université Aix Marseille, Team Physiopathology of Cardiac Development, Faculté de Medecine La Timone, Marseille, France (M.P.); and Biology Department, Integrated Regenerative Research Institute, San Diego State University, CA (M.A.S.). heartman4ever@icloud.com.
Joshua GoldhaberFrom the Departments of Internal Medicine and Molecular Physiology & Biophysics, Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City (M.E.A); Cedars-Sinai Heart Institute, Los Angeles, CA (J.G.); Department of Physiology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.R.H.); INSERM UMR 910, Génétique médicale et génomique fonctionnelle, Université Aix Marseille, Team Physiopathology of Cardiac Development, Faculté de Medecine La Timone, Marseille, France (M.P.); and Biology Department, Integrated Regenerative Research Institute, San Diego State University, CA (M.A.S.).
Steven R HouserFrom the Departments of Internal Medicine and Molecular Physiology & Biophysics, Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City (M.E.A); Cedars-Sinai Heart Institute, Los Angeles, CA (J.G.); Department of Physiology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.R.H.); INSERM UMR 910, Génétique médicale et génomique fonctionnelle, Université Aix Marseille, Team Physiopathology of Cardiac Development, Faculté de Medecine La Timone, Marseille, France (M.P.); and Biology Department, Integrated Regenerative Research Institute, San Diego State University, CA (M.A.S.).
Michel PuceatFrom the Departments of Internal Medicine and Molecular Physiology & Biophysics, Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City (M.E.A); Cedars-Sinai Heart Institute, Los Angeles, CA (J.G.); Department of Physiology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.R.H.); INSERM UMR 910, Génétique médicale et génomique fonctionnelle, Université Aix Marseille, Team Physiopathology of Cardiac Development, Faculté de Medecine La Timone, Marseille, France (M.P.); and Biology Department, Integrated Regenerative Research Institute, San Diego State University, CA (M.A.S.).
Mark A SussmanFrom the Departments of Internal Medicine and Molecular Physiology & Biophysics, Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City (M.E.A); Cedars-Sinai Heart Institute, Los Angeles, CA (J.G.); Department of Physiology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.R.H.); INSERM UMR 910, Génétique médicale et génomique fonctionnelle, Université Aix Marseille, Team Physiopathology of Cardiac Development, Faculté de Medecine La Timone, Marseille, France (M.P.); and Biology Department, Integrated Regenerative Research Institute, San Diego State University, CA (M.A.S.).
Funding
Surgery, Physiology and ImmunohistopathologyP01HL085577 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2006 to 2017
$18.4MRegulation of Signal Transduction to Treat Heart FailureR01HL067245 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2001 to 2021
$6.0MMolecular Biology of Cardiac Sodium-Calcium ExchangeR01HL048509 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLDHABER, JOSHUA I, PHILIPSON, KENNETH · 2002 to 2016
$4.7MMetabolic Regulation of Cardiac E-C CouplingR01HL070828 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLDHABER, JOSHUA I · 2002 to 2013
$3.8MStem Cell Signaling in the Pathologically Challenged MyocardiumR37HL091102 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2008 to 2017
$3.8MBeta-adrenergic signaling: double edged sword of myocardial repairR01HL117163 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2013 to 2017
$1.9MAntagonism of myocardial aging and senescence with Pim-1 kinaseR01HL105759 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2011 to 2015
$1.8MEnhanced Myocardial Repair with CardioClusters and CardioChimerasR01HL122525 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2014 to 2017
$1.5MCardioprotection by optimizing mTOR activityR01HL113647 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2013 to 2016
$1.5MMolecular Engineering of Damaged Myocardium To Enhance Regeneration And RepairR01HL113656 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2012 to 2013
$667kNHLBI NIH HHS P01 HL085577NHLBI NIH HHS R01 HL048509NHLBI NIH HHS R01 HL067245NHLBI NIH HHS R01HL067245NHLBI NIH HHS R01 HL070828NHLBI NIH HHS R01 HL105759NHLBI NIH HHS R01HL105759NHLBI NIH HHS R01 HL113647NHLBI NIH HHS R01 HL113656NHLBI NIH HHS R01 HL117163NHLBI NIH HHS R01 HL122525NHLBI NIH HHS R37 HL091102NHLBI NIH HHS R37HL091102
Abstract
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Indexed as
HeartRegenerationAnimalsEmbryonic Stem CellsHumansMaleMyocardial InfarctionMyocytes, Cardiac
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.