Evidence map›Paper›PMID 24935945›Full record

ArticleHypertension (Dallas, Tex. : 1979)2014

Systolic and diastolic blood pressure, incident cardiovascular events, and death in elderly persons: the role of functional limitation in the Cardiovascular Health Study.

Carmen A Peralta, Ronit Katz, Anne B Newman, Bruce M Psaty, Michelle C Odden

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  5. Characterizing Frailty Status in the Systolic Blood Pressure Intervention Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016
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  6. Multidimensional functional limitations in American cancer survivors: Characteristics and their effects on survival and healthcare utilization.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  20. Patterns of Cardiovascular Risk Factors in Old Age and Survival and Health Status at 90.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Carmen A PeraltaFrom the Department of Medicine, University of California, San Francisco (C.A.P.), Nephrology Division, San Francisco VA Medical Center, CA (C.A.P.); Kidney Research Institute (R.K.) and Cardiovascular Health Research Unit (B.M.P.), University of Washington, Seattle; Department of Epidemiology, University of Pittsburgh, PA (A.B.N.); College of Public Health and Human Sciences, Oregon State University, Corvallis (M.C.O.). carmenalicia.peralta@ucsf.edu.
Ronit KatzFrom the Department of Medicine, University of California, San Francisco (C.A.P.), Nephrology Division, San Francisco VA Medical Center, CA (C.A.P.); Kidney Research Institute (R.K.) and Cardiovascular Health Research Unit (B.M.P.), University of Washington, Seattle; Department of Epidemiology, University of Pittsburgh, PA (A.B.N.); College of Public Health and Human Sciences, Oregon State University, Corvallis (M.C.O.).
Anne B NewmanFrom the Department of Medicine, University of California, San Francisco (C.A.P.), Nephrology Division, San Francisco VA Medical Center, CA (C.A.P.); Kidney Research Institute (R.K.) and Cardiovascular Health Research Unit (B.M.P.), University of Washington, Seattle; Department of Epidemiology, University of Pittsburgh, PA (A.B.N.); College of Public Health and Human Sciences, Oregon State University, Corvallis (M.C.O.).
Bruce M PsatyFrom the Department of Medicine, University of California, San Francisco (C.A.P.), Nephrology Division, San Francisco VA Medical Center, CA (C.A.P.); Kidney Research Institute (R.K.) and Cardiovascular Health Research Unit (B.M.P.), University of Washington, Seattle; Department of Epidemiology, University of Pittsburgh, PA (A.B.N.); College of Public Health and Human Sciences, Oregon State University, Corvallis (M.C.O.).
Michelle C OddenFrom the Department of Medicine, University of California, San Francisco (C.A.P.), Nephrology Division, San Francisco VA Medical Center, CA (C.A.P.); Kidney Research Institute (R.K.) and Cardiovascular Health Research Unit (B.M.P.), University of Washington, Seattle; Department of Epidemiology, University of Pittsburgh, PA (A.B.N.); College of Public Health and Human Sciences, Oregon State University, Corvallis (M.C.O.).
University of Washington · USUniversity of Pittsburgh · US

Funding

Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Role of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9M
A New Paradigm for Hypertension in the Elderly- Beyond AgeR01AG046206 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI ODDEN, MICHELLE CHRISTINA, PERALTA, CARMEN ALICIA · 2014 to 2018
$1.4M
Modeling Optimal Strategies to Prevent Cardiovascular Events in Older AdultsK01AG039387 · NIA · OREGON STATE UNIVERSITY · PI ODDEN, MICHELLE CHRISTINA · 2012 to 2016
$688k
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R56AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2010 to 2010
$300k
CENTRAL BLOOD ANALYSIS LABORATORY FOR CHSN01HC085086 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1988 to 2000
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CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84N01HC085082 · HC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KULLER, LEWIS H · 1988 to 2000
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CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085081 · HC · JOHNS HOPKINS UNIVERSITY · PI FRIED, LINDA P · 1988 to 2000
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CORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1988 to 2000
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CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · HC · UNIVERSITY OF WASHINGTON · 1988 to 2005
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NHLBI NIH HHS HL080295NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL080295NHLBI NIH HHS U01 HL080295NIA NIH HHS AG023629NIA NIH HHS K01 AG039387NIA NIH HHS K01AG039387NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG046206NIA NIH HHS R56 AG023629PHS HHS K23SK082793
6 · The paper itself

Abstract

Whether limitation in the ability to perform activities of daily living (ADL) or gait speed can identify elders in whom the association of systolic and diastolic blood pressure (DBP) with cardiovascular events (CVDs) and death differs is unclear. We evaluated whether limitation in ADL or gait speed modifies the association of systolic blood pressure or DBP with incident CVD (n=2358) and death (n=3547) in the Cardiovascular Health Study. Mean age was 78±5 and 21% reported limitation in ≥1 ADL. There were 778 CVD and 1289 deaths over 9 years. Among persons without and those with ADL limitation, systolic blood pressure was associated with incident CVD: hazard ratio [HR] (per 10-mm Hg increase) 1.08 (95% confidence interval, 1.03, 1.13) and 1.06 (0.97, 1.17), respectively. ADL modified the association of DBP with incident CVD. Among those without ADL limitation, DBP was weakly associated with incident CVD, HR 1.04 (0.79, 1.37) for DBP >80, compared with <65 mm Hg. Among those with ADL limitation, DBP was inversely associated with CVD: HR 0.65 (0.44, 0.96) for DBP 66 to 80 mm Hg and HR 0.49 (0.25, 0.94) for DBP >80, compared with DBP ≤65. Among people with ADL limitation, a DBP of 66 to 80 had the lowest risk of death, HR 0.72 (0.57, 0.91), compared with a DBP of ≤65. Associations did not vary by 15-feet walking speed. ADL can identify elders in whom diastolic hypotension is associated with higher cardiovascular risk and death. Functional status, rather than chronologic age alone, should inform design of hypertension trials in elders.

Indexed as

Activities of Daily LivingAgedAged, 80 and overBlack PeopleBlood PressureCardiovascular DiseasesDiastoleFemaleFollow-Up StudiesGaitHeart RateHumansIncidenceLongitudinal StudiesMaleRisk Factorsactivities of daily livingagedhypertension

Identifiers

PMID24935945
PMCPMC4134400
OpenAlexW2129451867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.