ArticleHypertension (Dallas, Tex. : 1979)2014
Sex-specific T-cell regulation of angiotensin II-dependent hypertension.
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Hypertension (Dallas, Tex. : 1979), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
What it found
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Who cites it
93 citing papers in PubMed, 130 citations in OpenAlex.
- Sex differences in TLR4 expression in SHR do not contribute to sex differences in blood pressure or the renal T cell profile.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Review
- B1a Cell-IgM Axis Protects Against Hypertension by Blunting IFNγ+CD4+T Cells.Circulation research · 2026Article
- Conditional ablation of RGS2 in myeloid cells does not influence blood pressure and organ damage in angiotensin II-induced hypertension in mice.Physiological reports · 2026Article
- Novel Advances in Our Understanding of Sex-Dependent Control of Blood Pressure.Annual review of physiology · 2026Review
- Rats exposed to a low resource environment in early life display sex differences in blood pressure, autonomic activity, and brain and kidney pro-inflammatory markers during adulthood.Biology of sex differences · 2026Article
- Sex dictates IL-17A regulation: Inflammatory determinants in males versus a potassium-linked metabolic axis in females.PloS one · 2026Article
- Rats Exposed to a Low Resource Environment in Early Life Display Sex Differences in Blood Pressure, Autonomic Activity, and Brain and Kidney Pro-inflammatory Markers During Adulthood.Research square · 2025Article
- T cell knockout attenuates HFD-induced increases in blood pressure in female and male Dahl rats.Clinical science (London, England : 1979) · 2025Article
- Rats Exposed to a Low Resource Environment in Early Life Display Sex Differences in Blood Pressure, Autonomic Activity, and Brain and Kidney Pro-inflammatory Markers During Adulthood.bioRxiv : the preprint server for biology · 2025Article
- Elevated LDL-C induces T-cell metabolic dysfunction and increases inflammation and oxidative stress in midlife adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Salt sensitivity of blood pressure: mechanisms and sex-specific differences.Nature reviews. Cardiology · 2025Review
- Annexin-A1 deficiency uncovers female-specific pathways in blood pressure control and cardiovascular remodeling in mice.Communications biology · 2025Article
- HMGB1 drives T-cell activation in hypertensive males and females.American journal of physiology. Renal physiology · 2025Article
- Recent advances on immunity and hypertension: the new cells on the kidney block.American journal of physiology. Renal physiology · 2025Review
- The role of T cells in vascular aging, hypertension, and atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2024Review
- Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024Review
- Sex-Dependency of T Cell-Induced Salt-Sensitive Hypertension and Kidney Damage.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024Review
- Mechanisms and consequences of sex differences in immune responses.Nature reviews. Nephrology · 2024Review
33 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 7 institutions in 3 countries.
Hong JiFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.). jih@georgetown.edu.
Wei ZhengFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Xiangjun LiFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Jun LiuFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Xie WuFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Monan Angela ZhangFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Jason G UmansFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Meredith HayFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Robert C SpethFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Shannon E DunnFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Kathryn SandbergFrom the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.).
Eastern University · USSoutheastern University · USGeorgetown-Howard Universities Center for Clinical and Translational Science · USMedStar Health · USUniversity Health Network · CAUniversity of Arizona · USUniversity of Toronto · CA
Funding
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUUL1TR000101 · NCATS · GEORGETOWN UNIVERSITY · PI MELLMAN, THOMAS A, VERBALIS, JOSEPH G · 2012 to 2015
$19.3MHORMONAL REGULATION OF ANGIOTENSIN RECEPTORSR01AG019291 · NIA · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2001 to 2011
$3.2MImmune Modulation of HypertensionR01HL119380 · NHLBI · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2015 to 2018
$2.4MGonadotropins in a female model of age-induced hypertensionR21AG039779 · NIA · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2011 to 2012
$388kOvarian hormone-independent sex chromosome effects in menopauseR21AG037832 · NIA · GEORGETOWN UNIVERSITY · PI JI, HONG · 2010 to 2011
$307kNCATS NIH HHS UL1 TR000101NHLBI NIH HHS R01 HL119380NIA NIH HHS AG-037832NIA NIH HHS R01 AG019291NIA NIH HHS R21 AG037832NIA NIH HHS R21 AG039779
Abstract
Studies suggest T cells modulate arterial pressure. Because robust sex differences exist in the immune system and in hypertension, we investigated sex differences in T-cell modulation of angiotensin II-induced increases in mean arterial pressure in male (M) and female (F) wild-type and recombination-activating-gene-1-deficient (Rag1(-/-)) mice. Sex differences in peak mean arterial pressure in wild-type were lost in Rag1(-/-) mice (mm Hg: wild-type-F, 136±4.9 versus wild-type-M, 153±1.7; P<0.02; Rag1(-/-)-F, 135±2.1 versus Rag1(-/-)-M, 141±3.8). Peak mean arterial pressure was 13 mm Hg higher after adoptive transfer of male (CD3(M)→Rag1(-/-)-M) versus female (CD3(F)→Rag1(-/-)-M) T cells. CD3(M)→Rag1(-/-)-M mice exhibited higher splenic frequencies of proinflammatory interleukin-17A (2.4-fold) and tumor necrosis factor-α (2.2-fold)-producing T cells and lower plasma levels (13-fold) and renal mRNA expression (2.4-fold) of interleukin-10, whereas CD3(F)→Rag1(-/-)-M mice displayed a higher activation state in general and T-helper-1-biased renal inflammation. Greater T-cell infiltration into perivascular adipose tissue and kidney associated with increased pressor responses to angiotensin II if the T cell donor was male but not female and these sex differences in T-cell subset expansion and tissue infiltration were maintained for 7 to 8 weeks within the male host. Thus, the adaptive immune response and role of pro- and anti-inflammatory cytokine signaling in hypertension are distinct between the sexes and need to be understood to improve therapeutics for hypertension-associated disease in both men and women.
Indexed as
Adaptive ImmunityAngiotensin IIAnimalsBlood PressureDisease Models, AnimalFemaleHeart RateHomeodomain ProteinsHypertensionInterleukin-10Interleukin-17MaleMiceMice, KnockoutSex FactorsT-LymphocytesAngiotensin IIHomeodomain ProteinsInterleukin-10Interleukin-17RAG-1 proteinTumor Necrosis Factor-alphaangiotensinshypertensioninterleukin 10 interleukin 17sex characteristicsT-lymphocytestumor necrosis factor-alpha
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