ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2014
The frequency of precocious segregation of sister chromatids in mouse female meiosis I is affected by genetic background.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 17 citations in OpenAlex.
- The Consequences of DNA Damage in the Early Embryo Are Important for Practical Procedures in Assisted Reproduction.International journal of molecular sciences · 2025Review
- Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?International journal of molecular sciences · 2024Review
- Selfish centromeres and the wastefulness of human reproduction.PLoS biology · 2022Article
- Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs.Current biology : CB · 2019Article
- Actin-microtubule interplay coordinates spindle assembly in human oocytes.Nature communications · 2019Article
- ProTAME Arrest in Mammalian Oocytes and Embryos Does Not Require Spindle Assembly Checkpoint Activity.International journal of molecular sciences · 2019Article
- Review
- Article
- Human oocytes. Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes.Science (New York, N.Y.) · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Mammalian female gametes frequently suffer from numerical chromosomal aberrations, the main cause of miscarriages and severe developmental defects. The underlying mechanisms responsible for the development of aneuploidy in oocytes are still not completely understood and remain a subject of extensive research. From studies focused on prevalence of aneuploidy in mouse oocytes, it has become obvious that reported rates of aneuploidy are strongly dependent on the method used for chromosome counting. In addition, it seems likely that differences between mouse strains could influence the frequency of aneuploidy as well; however, up till now, such a comparison has not been available. Therefore, in our study, we measured the levels of aneuploidy which has resulted from missegregation in meiosis I, in oocytes of three commonly used mouse strains-CD-1, C3H/HeJ, and C57BL/6. Our results revealed that, although the overall chromosomal numerical aberration rates were similar in all three strains, a different number of oocytes in each strain contained prematurely segregated sister chromatids (PSSC). This indicates that a predisposition for this type of chromosome segregation error in oocyte meiosis I is dependent on genetic background.
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