Trial reportBMC pediatrics2014
Comparison of clinical and biochemical markers of dehydration with the clinical dehydration scale in children: a case comparison trial.
Trial report in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00462527 (Cystatin C as a Marker for Detecting Early Renal Dysfunction in a Pediatric Emergency Department), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cystatin C as a Marker for Detecting Early Renal Dysfunction in a Pediatric Emergency Department
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Efficacy of bioelectrical impedance analysis during the perioperative period in children.Journal of clinical monitoring and computing · 2017Trial
- Xyloglucan for the treatment of acute diarrhea: results of a randomized, controlled, open-label, parallel group, multicentre, national clinical trial.BMC gastroenterology · 2015Trial
- Antibiotic Resistance Trends and Prescribing Patterns in Pediatric Non-TyphoidalInfection and drug resistance · 2026Article
- Heart rate to identify non-febrile children with dehydration and acute kidney injury in emergency department: a prospective validation study.European journal of pediatrics · 2024Article
- Dehydration associates with lower urinary tract symptoms in progressive multiple sclerosis.European journal of neurology · 2024Article
- Perioperative water and electrolyte balance and water homeostasis regulation in children with acute surgery.Pediatric research · 2023Observational
- Impact of rotavirus vaccine implementation on Israeli children: a comparison between pre- and post-vaccination era.World journal of pediatrics : WJP · 2022Observational
- Does Serum Zinc Level Affect Severity of Acute Gastroenteritis Among Pre-School Thai Children?Pediatric health, medicine and therapeutics · 2021Article
- Elevated Serum Uric Acid in Benign Convulsions with Mild Gastroenteritis in Children.Journal of clinical neurology (Seoul, Korea) · 2019Article
- Sodium and water homeostasis in children admitted with acute appendicitis: a prospective study.Pediatric research · 2019Observational
- Pediatric Dehydration Assessment at Triage: Prospective Study on Refilling Time.Pediatric gastroenterology, hepatology & nutrition · 2018Article
- Review
- Gastroduodenal Perforation and Ulcer Associated With Rotavirus and Norovirus Infections in Japanese Children: A Case Report and Comprehensive Literature Review.Open forum infectious diseases · 2016Article
- Empirically Derived Dehydration Scoring and Decision Tree Models for Children With Diarrhea: Assessment and Internal Validation in a Prospective Cohort Study in Dhaka, Bangladesh.Global health, science and practice · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical dehydration scale (CDS) is a quick, easy-to-use tool with 4 clinical items and a score of 1-8 that serves to classify dehydration in children with gastroenteritis as no, some or moderate/severe dehydration. Studies validating the CDS (Friedman JN) with a comparison group remain elusive. We hypothesized that the CDS correlates with a wide spectrum of established markers of dehydration, making it an appropriate and easy-to-use clinical tool.
methodsThis study was designed as a prospective double-cohort trial in a single tertiary care center. Children with diarrhea and vomiting, who clinically required intravenous fluids for rehydration, were compared with minor trauma patients who required intravenous needling for conscious sedation. We compared the CDS with clinical and urinary markers (urinary electrolytes, proteins, ratios and fractional excretions) for dehydration in both groups using receiver operating characteristic (ROC) curves to determine the area under the curve (AUC).
resultsWe enrolled 73 children (male = 36) in the dehydration group and 143 (male = 105) in the comparison group. Median age was 32 months (range 3-214) in the dehydration and 96 months (range 2.6-214 months, p < 0.0001) in the trauma group. Median CDS was 3 (range 0-8) within the dehydration group and 0 in the comparison group (p < 0.0001). The following parameters were statistically significant (p < 0.05) between the comparison group and the dehydrated group: difference in heart rate, diastolic blood pressure, urine sodium/potassium ratio, urine sodium, fractional sodium excretion, serum bicarbonate, and creatinine measurements. The best markers for dehydration were urine Na and serum bicarbonate (ROC AUC = 0.798 and 0.821, respectively). CDS was most closely correlated with serum bicarbonate (Pearson r = -0.3696, p = 0.002).
conclusionAlthough serum bicarbonate is not the gold standard for dehydration, this study provides further evidence for the usefulness of the CDS as a dehydration marker in children.
trial registrationRegistered at ClinicalTrials.gov (NCT00462527) on April 18, 2007.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.