ArticleMolecular brain2014
Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain.
Article in Molecular brain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
55 citing papers in PubMed, 85 citations in OpenAlex.
- Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice.Molecular pain · 2022Trial
- Optogenetic activation of cortical microglia promotes neuronal activity and pain hypersensitivity.Cell reports · 2025Article
- Cortical Potentiation in Chronic Neuropathic Pain and the Future Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis.Frontiers in pharmacology · 2025Review
- Antinociceptive effects of gamma-linolenic acid in the formalin test in the rats.Annals of medicine and surgery (2012) · 2024Article
- Neural circuits regulating visceral pain.Communications biology · 2024Review
- Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice.Molecular brain · 2024Article
- Unveiling the efficacy of paroxetine and gabapentin in ulcerative colitis patients in remission with co-existing IBS-like symptoms: a single-blinded randomized clinical trial.Frontiers in medicine · 2024Article
- The anti-inflammatory effect of dimethyl trisulfide in experimental acute pancreatitis.Scientific reports · 2023Article
- Article
- Electrophysiology as a Tool to Decipher the Network Mechanism of Visceral Pain in Functional Gastrointestinal Disorders.Diagnostics (Basel, Switzerland) · 2023Review
- Proanthocyanidins induce analgesic and anxiolytic effects in spared nerve injured mice by decreasingFrontiers in molecular neuroscience · 2023Article
- Cortical Synaptic Mechanism for Chronic Pain and Anxiety in Parkinson's Disease.Journal of translational internal medicine · 2022Article
- Enhancement of behavioral nociceptive responses but not itching responses by viewing mirror images in adult mice.Molecular pain · 2022Article
- Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats.Neuroscience bulletin · 2022Article
- Supraspinal Mechanisms of Intestinal Hypersensitivity.Cellular and molecular neurobiology · 2022Review
- Neurotransmitter and Intestinal Interactions: Focus on the Microbiota-Gut-Brain Axis in Irritable Bowel Syndrome.Frontiers in endocrinology · 2022Review
- Intestinal anti-inflammatory and visceral analgesic effects of aFrontiers in pharmacology · 2022Article
- Spinal cord stimulation reduces cardiac pain through microglial deactivation in rats with chronic myocardial ischemia.Molecular medicine reports · 2021Article
- Effects of red ginseng on gut, microbiota, and brain in a mouse model of post-infectious irritable bowel syndrome.Journal of ginseng research · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Irritable bowel syndrome (IBS) is characterized by recurrent abdominal discomfort, spontaneous pain, colorectal hypersensitivity and bowel dysfunction. Patients with IBS also suffer from emotional anxiety and depression. However, few animal studies have investigated IBS-induced spontaneous pain and behavioral anxiety. In this study, we assessed spontaneous pain and anxiety behaviors in an adult mouse model of IBS induced by zymosan administration. By using Fos protein as a marker, we found that sensory and emotion related brain regions were activated at day 7 after the treatment with zymosan; these regions include the prefrontal cortex, anterior cingulate cortex, insular cortex and amygdala. Behaviorally, zymosan administration triggered spontaneous pain (decreased spontaneous activities in the open field test) and increased anxiety-like behaviors in three different tests (the open field, elevated plus maze and light/dark box tests). Intraperitoneal injection of NB001, an adenylyl cyclase 1 (AC1) inhibitor, reduced spontaneous pain but had no significant effect on behavioral anxiety. In contrast, gabapentin reduced both spontaneous pain and behavioral anxiety. These results indicate that NB001 and gabapentin may inhibit spontaneous pain and anxiety-like behaviors through different mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.