ArticleJournal of inorganic biochemistry2014
Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains.
Article in Journal of inorganic biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- The Many Lives of Auranofin: How an Old Anti-Rheumatic Agent May Become a Promising Antimicrobial Drug.Antibiotics (Basel, Switzerland) · 2024Review
- Gold Nanoclusters as Nanoantibiotic Auranofin Analogues.Advanced healthcare materials · 2022Article
- Auranofin Has Advantages over First-Line Drugs in the Treatment of SevereAntibiotics (Basel, Switzerland) · 2020Article
- Synthesis, Molecular Docking and Cytotoxic Activity Evaluation of Organometallic Thiolated Gold(I) Complexes.Iranian journal of pharmaceutical research : IJPR · 2020Article
- Sugar-Modified Analogs of Auranofin Are Potent Inhibitors of the Gastric PathogenACS infectious diseases · 2019Article
- Synthesis and Structure-Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens.Journal of medicinal chemistry · 2019Article
- Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents.Scientific reports · 2019Article
- Article
- Inhibition Mechanism of Urease by Au(III) Compounds Unveiled by X-ray Diffraction Analysis.ACS medicinal chemistry letters · 2019Article
- Better living through chemistry: Addressing emerging antibiotic resistance.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System.Frontiers in microbiology · 2018Review
- Biscarbene gold(i) complexes: structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability.MedChemComm · 2017Article
- Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.Virulence · 2017Article
- Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway.Frontiers in cellular and infection microbiology · 2017Article
- Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms.Antimicrobial agents and chemotherapy · 2016Article
- Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens.Scientific reports · 2016Article
- Repurposing auranofin for the treatment of cutaneous staphylococcal infections.International journal of antimicrobial agents · 2016Article
- Auranofin-loaded nanoparticles as a new therapeutic tool to fight streptococcal infections.Scientific reports · 2016Article
- Assay of Blood and Synovial Fluid of Patients With Rheumatoid Arthritis for Staphylococcus aureus Enterotoxin D: Absence of Bacteria But Presence of Its Toxin.Jundishapur journal of microbiology · 2015Article
- Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
A series of new heterometallic gold(I) thiolates containing ferrocenyl-phoshines were synthesized. Their antimicrobial properties were studied and compared to that of FDA-approved drug, auranofin (Ridaura), prescribed for the treatment of rheumatoid arthritis. MIC in the order of one digit micromolar were found for most of the compounds against Gram-positive bacteria Staphylococcus aureus and CA MRSA strains US300 and US400. Remarkably, auranofin inhibited S. aureus, US300 and US400 in the order of 150-300 nM. This is the first time that the potent inhibitory effect of auranofin on MRSA strains has been described. The effects of a selected heterometallic compound and auranofin were also studied in a non-tumorigenic human embryonic kidney cell line (HEK-293).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.