Trial reportThe American journal of psychiatry2014
Sequential treatment with fluoxetine and relapse--prevention CBT to improve outcomes in pediatric depression.
Trial report in The American journal of psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00612313 (Pediatric MDD), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pediatric MDD: Sequential Treatment With Fluoxetine and Relapse Prevention
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- Deprescribing Antidepressants in Children and Adolescents: A Systematic Review of Discontinuation Approaches, Cross-Titration, and Withdrawal Symptoms.Journal of child and adolescent psychopharmacology · 2025Pooled it
- A Multisite, 6-Month, Open-Label Study of Maintenance Transcranial Magnetic Stimulation for Adolescents with Treatment-Resistant Depression.Journal of child and adolescent psychopharmacology · 2025Trial
- Well-Being Therapy as Rehabilitation Therapy for Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial.Journal of traumatic stress · 2020Trial
- Lithium for the Maintenance Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Discontinuation Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Trial
- Trial
- Continued Effectiveness of Relapse Prevention Cognitive-Behavioral Therapy Following Fluoxetine Treatment in Youth With Major Depressive Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2015Trial
- One Health approach to mental health- mental health recovery in times of crisis: conference proceeding.BMC proceedings · 2026Article
- Validation of the Brief Children's Depression Rating Scale in Children Treated With Selegiline Transdermal Patch vs Placebo.JAACAP open · 2026Article
- Article
- Evidence for various interventions to reduce depressive symptoms for children and adolescents: protocol of a global evidence and gap map.Systematic reviews · 2025Article
- Performance and Psychometric Properties of Novel Brief Assessments for Depression in Children and Adolescents.JAACAP open · 2025Article
- A Novel Blended Transdiagnostic Intervention (eOrygen) for Youth Psychosis and Borderline Personality Disorder: Uncontrolled Single-Group Pilot Study.JMIR mental health · 2024Article
- Well-Being Therapy for Depression.Advances in experimental medicine and biology · 2024Review
- [The German S3 guideline for depressive disorders in childhood and adolescence: new developments].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023Review
- Congruency of multimodal data-driven personalization with shared decision-making for StayFine: individualized app-based relapse prevention for anxiety and depression in young people.Frontiers in psychiatry · 2023Article
- Article
- Can Fluoxetine Combined with Cognitive Behavioral Therapy Reduce the Suicide and Non-Suicidal Self-Injury Incidence and Recurrence Rate in Depressed Adolescents Compared with Fluoxetine Alone? A Meta-Analysis.Neuropsychiatric disease and treatment · 2022Review
- Neurocognitive and functional heterogeneity in depressed youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Well-being Therapy in Depressive Disorders.Advances in experimental medicine and biology · 2021Review
- The pursuit of euthymia.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe authors evaluated a sequential treatment strategy of fluoxetine and relapse-prevention cognitive-behavioral therapy (CBT) to determine effects on remission and relapse in youths with major depressive disorder.
methodYouths 8-17 years of age with major depression were treated openly with fluoxetine for 6 weeks. Those with an adequate response (defined as a reduction of 50% or more on the Children's Depression Rating Scale-Revised [CDRS-R]) were randomly assigned to receive continued medication management alone or continued medication management plus CBT for an additional 6 months. The CBT was modified to address residual symptoms and was supplemented by well-being therapy. Primary outcome measures were time to remission (with remission defined as a CDRS-R score of 28 or less) and rate of relapse (with relapse defined as either a CDRS-R score of 40 or more with a history of 2 weeks of symptom worsening, or clinical deterioration).
resultsOf the 200 participants enrolled in acute-phase treatment, 144 were assigned to continuation treatment with medication management alone (N=69) or medication management plus CBT (N=75). During the 30-week continuation treatment period, time to remission did not differ significantly between treatment groups (hazard ratio=1.26, 95% CI=0.87, 1.82). However, the medication management plus CBT group had a significantly lower risk of relapse than the medication management only group (hazard ratio=0.31, 95% CI=0.13, 0.75). The estimated probability of relapse by week 30 was lower with medication management plus CBT than with medication management only (9% compared with 26.5%).
conclusionsContinuation-phase relapse-prevention CBT was effective in reducing the risk of relapse but not in accelerating time to remission in children and adolescents with major depressive disorder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.