Evidence map›Paper›PMID 24935068›Full record

SynthesisMedical science monitor : international medical journal of experimental and clinical research2014

Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta-analysis.

Lieliang Zhang, Juan Zhu, Lei Xu, Xunlei Zhang, Hongyu Wang, Zhonghua Luo, Yamei Zhao, Yi Yu, Yong Zhang, Hongwei Shi and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  7. Etomidate-remifentanil is more suitable for monitored anesthesia care during gastroscopy in older patients than propofol-remifentanil.Medical science monitor : international medical journal of experimental and clinical research · 2015
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  13. Effectiveness of Different Doses of Tenoxicam in Preventing Propofol Injection Pain.Turkish journal of anaesthesiology and reanimation · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lieliang ZhangDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Juan ZhuDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Lei XuDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Xunlei ZhangDepartment of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Hongyu WangDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Zhonghua LuoDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Yamei ZhaoDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Yi YuDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Yong ZhangDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Hongwei ShiDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Hongguang BaoDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China (mainland).
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPain on injection is an acknowledged adverse effect (AE) of propofol administration for the induction of general anesthesia. Flurbiprofen axetil has been reported to reduce the pain of injection. However, results of published papers on the efficacy of flurbiprofen axetil in managing pain on injection of propofol are inconsistent. MATERIAL/

methodsWe conducted a comprehensive meta-analysis of studies to appraise the efficacy and safety of flurbiprofen axetil for controlling pain induced by propofol injection. The pooled risk ratio (RR) with corresponding 95% confidence intervals (CI) was calculated employing fixed- or random-effects models, depending upon the heterogeneity of the included trials.

resultsCompared with the placebo group, flurbiprofen axetil allows more patients to have no pain (RR 3.51, 95% CI 2.22-5.55, p=0.000), and decreases the cumulative number of patients with mild, moderate, and severe pain on injecting propofol (RR 0.70, 95% CI 0.58-0.86, p=0.000; RR 0.59, 95% CI 0.46-0.75, p=0.000; RR 0.25, 95% CI 0.16-0.38, p=0.000, respectively). In the stratified analysis by the doses, flurbiprofen axetil at a dose of over 50 mg was found to be effective in reducing propofol-induced pain on injection; however, there were no significant differences in relieving pain between treatment and placebo groups with flurbiprofen axetil at a dose of 25 mg. In terms of drug safety, there were no adverse effects (AEs) reported between flurbiprofen axetil-based regimens and placebo regimens.

conclusionsFlurbiprofen axetil, an injectable prodrug of flurbiprofen, can significantly prevent or relieve the pain induced by propofol injection. More studies are required to assess its adverse effects.

Indexed as

Clinical Trials as TopicFlurbiprofenHumansPainPropofolPublication BiasRisk FactorsTreatment OutcomeFlurbiprofenflurbiprofen axetilPropofol

Identifiers

PMID24935068
PMCPMC4070992
OpenAlexW2166860228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.