ArticleThe Journal of cell biology1989
Activators of protein kinase C trigger cortical granule exocytosis, cortical contraction, and cleavage furrow formation in Xenopus laevis oocytes and eggs.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 108 citations in OpenAlex.
- TheBiomolecules · 2025Review
- Spontaneous Overactivation ofInternational journal of molecular sciences · 2024Article
- Oxidative Stress-Induced Overactivation of Frog Eggs Triggers Calcium-Dependent Non-Apoptotic Cell Death.Antioxidants (Basel, Switzerland) · 2022Article
- Knockin' on Egg's Door: Maternal Control of Egg Activation That Influences Cortical Granule Exocytosis in Animal Species.Frontiers in cell and developmental biology · 2021Review
- Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in theProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Phospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development.Developmental biology · 2015Review
- Calcium signaling and meiotic exit at fertilization in Xenopus egg.International journal of molecular sciences · 2014Review
- Endogenous lactate transport in Xenopus laevis oocyte: dependence on cytoskeleton and regulation by protein kinases.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Article
- A role for myosin 1e in cortical granule exocytosis in Xenopus oocytes.The Journal of biological chemistry · 2007Article
- Control of local actin assembly by membrane fusion-dependent compartment mixing.Nature cell biology · 2007Article
- Calcium at fertilization and in early development.Physiological reviews · 2006Review
- Interaction between constitutively expressed heat shock protein, Hsc 70, and cysteine string protein is important for cortical granule exocytosis in Xenopus oocytes.The Journal of biological chemistry · 2005Article
- Analysis of cortical flow models in vivo.Molecular biology of the cell · 2000Article
- Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP.The Journal of cell biology · 2000Article
- Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- sn-1,2-diacylglycerol and choline increase after fertilization in Xenopus laevis.Molecular biology of the cell · 1997Article
- Evidence that the ability to respond to a calcium stimulus in exocytosis is determined by the secretory granule membrane: comparison of exocytosis of injected bovine chromaffin granule membranes and endogenous cortical granules in Xenopus laevis oocytes.Cellular and molecular neurobiology · 1994Article
- Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes.Molecular and cellular biology · 1992Article
- Meiosis, egg activation, and nuclear envelope breakdown are differentially reliant on Ca2+, whereas germinal vesicle breakdown is Ca2+ independent in the mouse oocyte.The Journal of cell biology · 1992Article
- Sodium dependence of the epithelial sodium conductance expressed in Xenopus laevis oocytes.Pflugers Archiv : European journal of physiology · 1991Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Prophase I oocytes, free of follicle cells, and metaphase II eggs of the amphibian Xenopus laevis were subjected to transient treatments with the protein kinase C activators, phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-didecanoate, and 1-olyeoyl-2-acetyl-sn-glycerol. In both oocytes and eggs, these treatments triggered early events of amphibian development: cortical granule exocytosis, cortical contraction, and cleavage furrow formation. Surprisingly, activation of oocytes occurred in the absence of meiotic resumption, resulting in cells with an oocytelike nucleus and interior cytoplasm, but with a zygotelike cortex. PMA-induced activation of oocytes and eggs did not require external calcium, a prerequisite for normal activation of eggs. PMA-induced activation of eggs was inhibited by retinoic acid, a known inhibitor of protein kinase C. In addition, pretreatment of eggs with retinoic acid prevented activation by mechanical stimulation and inhibited activation by calcium ionophore A23187. The results suggest that protein kinase C activation is an integral component of the Xenopus fertilization pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.