ArticleLipids2014
Enhanced solubility and oral bioavailability of γ-tocotrienol using a self-emulsifying drug delivery system (SEDDS).
Article in Lipids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Tocotrienol-Incorporated Gelatin Hydrogel Crosslinked with Genipin for Future Bone Tissue Engineering Applications: Physiochemical Characterization and Biocompatibility.International journal of molecular sciences · 2026Article
- Shifting Perspectives on the Role of Tocotrienol vs. Tocopherol in Brain Health: A Scoping Review.International journal of molecular sciences · 2025Article
- Development and Optimization of Nano-Hydroxyapatite Encapsulating Tocotrienol-Rich Fraction Formulation Using Response Surface Methodology.Pharmaceutics · 2024Article
- Updates in the skeletal and joint protective effects of tocotrienol: a mini review.Frontiers in endocrinology · 2024Review
- Strategies to Enhance the Solubility and Bioavailability of Tocotrienols Using Self-Emulsifying Drug Delivery System.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Exploring the anti-inflammatory activities, mechanism of action and prospective drug delivery systems of tocotrienol to target neurodegenerative diseases.F1000Research · 2023Review
- Increasing Cellular Uptake and Permeation of Curcumin Using a Novel Polymer-Surfactant Formulation.Biomolecules · 2022Article
- Self-Emulsifying Systems for Delivery of Bioactive Compounds from Natural Origin.AAPS PharmSciTech · 2022Review
- Lipid-Based Nanocarrier System for the Effective Delivery of Nutraceuticals.Molecules (Basel, Switzerland) · 2021Review
- Tocotrienols: Dietary Supplements for Chronic Obstructive Pulmonary Disease.Antioxidants (Basel, Switzerland) · 2021Review
- Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide.Scientific reports · 2021Article
- Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability.International journal of nanomedicine · 2020Review
- The Role of Tocotrienol in Preventing Male Osteoporosis-A Review of Current Evidence.International journal of molecular sciences · 2019Review
- Use of Lipid Nanocarriers to Improve Oral Delivery of Vitamins.Nutrients · 2019Review
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans).Antioxidants (Basel, Switzerland) · 2018Review
- Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities.Nutrition & metabolism · 2018Review
- Lipid-associated oral delivery: Mechanisms and analysis of oral absorption enhancement.Journal of controlled release : official journal of the Controlled Release Society · 2016Review
- Evaluation of Pharmacokinetics, and Bioavailability of Higher Doses of Tocotrienols in Healthy Fed Humans.Journal of clinical & experimental cardiology · 2016Article
- Production of Nanoemulsions from Palm-Based Tocotrienol Rich Fraction by Microfluidization.Molecules (Basel, Switzerland) · 2015Article
- Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability.Molecules (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the in vitro and in vivo performance of γ-tocotrienol (γ-T3) incorporated in a self-emulsifying drug delivery system (SEDDS) and to compare its enhanced performance to a commercially available product, namely Tocovid Suprabio™ (hereafter Tocovid), containing tocotrienols. The solubilization of γ-T3 was tested in a dynamic in vitro lipolysis model followed by in vitro cellular uptake study for the lipolysis products. In addition, in vitro uptake studies using Caco2 cells were conducted at different concentrations of γ-T3 prepared as SEDDS, Tocovid, or mixed micelles. γ-T3 incorporated in SEDDS or Tocovid was orally administered to rats at different doses and absolute oral bioavailability from both formulations were determined. The dynamic in vitro lipolysis experiment showed about two fold increase in the solubilization of γ-T3 prepared as SEDDS compared to Tocovid, which correlated with higher cellular uptake in the subsequent uptake studies. In vitro cellular uptake and in vivo oral bioavailability studies have shown a twofold increase in the cellular uptake and oral bioavailability of γ-T3 incorporated in SEDDS compared to Tocovid as a result of improvement in its solubility and passive uptake as confirmed by in vitro studies. In conclusion, incorporation of γ-T3 in SEDDS formulation enhanced γ-T3 solubilization and passive permeability, thus its cellular uptake and oral bioavailability when compared to Tocovid.
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Registered trials
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