ReviewJournal of biomaterials applications2014
Development and hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity.
Review in Journal of biomaterials applications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Nitric oxide-releasing dextran surface with enhanced albumin affinity mitigates infection and foreign body reaction.Carbohydrate polymers · 2026Article
- Extracorporeal Support Vascular Access: 3D Printing Custom Cannulas.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Polymeric Fibrous Materials for Procoagulant and Anticoagulant Applications: A Review of Molecular Blood-Material Mechanisms and Strategies.Materials (Basel, Switzerland) · 2026Review
- Surface Engineering for Endothelium-Mimicking Functions to Combat Infection and Thrombosis in Extracorporeal Life Support Technologies.Advanced healthcare materials · 2024Article
- Predictive Methods for Thrombus Formation in the Treatment of Aortic Dissection and Cerebral Aneurysms: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2024Review
- The effects of nitric oxide on coagulation and inflammation in ex vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass.Artificial organs · 2023Article
- Bio-inspired hemocompatible surface modifications for biomedical applications.Progress in materials science · 2022Article
- Combination strategies for antithrombotic biomaterials: an emerging trend towards hemocompatibility.Biomaterials science · 2021Article
- Hemodynamic adaptation of heart failure to percutaneous venoarterial extracorporeal circulatory supports.Physiological research · 2020Review
- Toward a Long-Term Artificial Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Review
- The optimal incubation time for in vitro hemocompatibility testing: Assessment using polymer reference materials under pulsatile flow with physiological wall shear stress conditions.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Synthesis and Characterization of a FluorinatedJournal of materials chemistry. B · 2018Article
- Adult veno-arterial extracorporeal life support.Journal of thoracic disease · 2018Review
- Synthesis and biocompatibility of an argatroban-modified polysulfone membrane that directly inhibits thrombosis.Journal of materials science. Materials in medicine · 2018Article
- Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO).Biomaterials science · 2016Review
- The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Hemocompatibility is the goal for any biomaterial contained in extracorporeal life supporting medical devices. The hallmarks for hemocompatibility include nonthrombogenicity, platelet preservation, and maintained platelet function. Both in vitro and in vivo assays testing for compatibility of the blood/biomaterial interface have been used over the last several decades to ascertain if the biomaterial used in medical tubing and devices will require systemic anticoagulation for viability. Over the last 50 years systemic anticoagulation with heparin has been the gold standard in maintaining effective extracorporeal life supporting. However, the biomaterial that maintains effective ECLS without the use of any systemic anticoagulant has remained elusive. In this review, the in vivo 4-h rabbit thrombogenicity model genesis will be described with emphasis on biomaterials that may require no systemic anticoagulation for extracorporeal life supporting longevity. These novel biomaterials may improve extracorporeal circulation hemocompatibility by preserving near resting physiology of the major blood components, the platelets and monocytes. The rabbit extracorporeal circulation model provides a complete assessment of biomaterial interactions with the intrinsic coagulation players, the circulating platelet and monocytes. This total picture of blood/biomaterial interaction suggests that this rabbit thrombogenicity model could provide a standardization for biomaterial hemocompatibility testing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.