Trial reportLearning & memory (Cold Spring Harbor, N.Y.)2014
Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans.
Trial report in Learning & memory (Cold Spring Harbor, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 84 citations in OpenAlex.
- Preventing fear return in humans: Music-based intervention during reactivation-extinction paradigm.PloS one · 2024Trial
- Trial
- Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder.PloS one · 2019Trial
- Who is studied in de novo fear conditioning paradigms? An examination of demographic and stimulus characteristics predicting fear learning.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018Trial
- Mood Regulation Focused CBT Based on Memory Reconsolidation, Reduced Suicidal Ideation and Depression in Youth in a Randomised Controlled Study.International journal of environmental research and public health · 2018Trial
- Modification of Fear Memory by Pharmacological and Behavioural Interventions during Reconsolidation.PloS one · 2016Trial
- How Fear Memory is Updated: From Reconsolidation to Extinction?Neuroscience bulletin · 2025Review
- Stage 2 Registered Report: Propositional Thought Is Sufficient for Imaginal Extinction as Shown by Contrasting Participants With Aphantasia, Simulated Aphantasia, and Controls.Psychophysiology · 2025Article
- Fear attenuation collaborations to optimize translation.Behavioral neuroscience · 2024Article
- Reconsolidation and Fear Extinction: An Update.Current topics in behavioral neurosciences · 2023Article
- Skin conductance levels and responses in Asian and White participants during fear conditioningPhysiology & behavior · 2022Article
- Is Reconsolidation a General Property of Memory?Frontiers in human neuroscience · 2021Review
- Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality.Scientific reports · 2020Article
- No persistent attenuation of fear memories in humans: A registered replication of the reactivation-extinction effect.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Impact of a reminder/extinction procedure on threat-conditioned pupil size and skin conductance responses.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Method for the identification of pharmacological intervention for the disruption of fear memory in PTSD-rat model.MethodsX · 2020Article
- Is it possible to modify fear memories in humans with extinction training within a single day?Psychological research · 2019Article
- Pavlov's Pain: the Effect of Classical Conditioning on Pain Perception and its Clinical Implications.Current pain and headache reports · 2019Review
- Exploring the boundaries of post-retrieval extinction in healthy and anxious individuals.Behaviour research and therapy · 2018Article
- A reminder before extinction strengthens episodic memory via reconsolidation but fails to disrupt generalized threat responses.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Extinction training during reconsolidation has been shown to persistently diminish conditioned fear responses across species. We investigated in humans if older fear memories can benefit similarly. Using a Pavlovian fear conditioning paradigm we compared standard extinction and extinction after memory reactivation 1 d or 7 d following acquisition. Participants who underwent extinction during reconsolidation showed no evidence of fear recovery, whereas fear responses returned in participants who underwent standard extinction. We observed this effect in young and old fear memories. Extending the beneficial use of reconsolidation to older fear memories in humans is promising for therapeutic applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.