Evidence map›Paper›PMID 24934221›Full record

ReviewThe British journal of ophthalmology2014

Recent advances in OCT imaging of the lamina cribrosa.

Ian A Sigal, Bo Wang, Nicholas G Strouthidis, Tadamichi Akagi, Michael J A Girard

Open access · hybridAbstract readReview
In one paragraph

Review in The British journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 84 citations in OpenAlex.

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  15. Optical Coherence Tomography and Glaucoma.Annual review of vision science · 2021
    Review
  16. Article
  17. Discovery and clinical translation of novel glaucoma biomarkers.Progress in retinal and eye research · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Ian A SigalDepartment of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bo WangDepartment of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nicholas G StrouthidisNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Tadamichi AkagiDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Michael J A GirardSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore In vivo Biomechanics Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
University of Pittsburgh · USKyoto University · JPNational University of Singapore · SGUniversity College London · GB

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ethan A Rossi · 1989 to 2026
$17.8M
Novel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5M
TRAINING PROGRAM FOR MD/PHD STUDENTST32GM008208 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEINMAN, RICHARD A · 1987 to 2021
$15.4M
Optic nerve head microstructure, biomechanics and susceptibility to glaucomaR01EY023966 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ian A Sigal · 2014 to 2026
$3.8M
NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY013178NEI NIH HHS R01 EY023966NIGMS NIH HHS T32 GM008208
6 · The paper itself

Abstract

The lamina cribrosa (LC) is believed to be the site of injury to retinal ganglion cell axons in glaucoma. The ability to visualise this structure has the potential to help increase our understanding of the disease and be useful in the early detection of glaucoma. While for many years the research on the LC was essentially dependent on histology and modelling, a number of recent advances in optical coherence tomography (OCT) have dramatically improved the ability to visualise the LC, such that it is now possible to image the LC in vivo in humans and animals. In this review, we highlight recent advances in OCT imaging of the LC, in the technology, processing and analysis, and discuss the impact that these will have on the ability to diagnose and monitor glaucoma, as well as to expand our understanding of its pathophysiology. With this manuscript, we aspire to share our excitement on the achievements and potential of recent developments as well as advise caution regarding the challenges that remain before imaging of the LC and optic nerve can be used routinely in clinical practice.

Indexed as

AnimalsGlaucomaHumansNerve FibersOptic DiskOptic Nerve DiseasesRetinal Ganglion CellsTomography, Optical CoherenceAnatomyGlaucomaImagingIntraocular PressureOptic Nerve

Identifiers

PMID24934221
PMCPMC4208343
OpenAlexW2130075876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.