ReviewNature reviews. Rheumatology2014
Vasculitis: determinants of disease patterns.
Review in Nature reviews. Rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Aortic involvement in relapsing polychondritis: case-based review.Rheumatology international · 2021Pooled it
- The current role of capillaroscopy in vasculitides.Clinical rheumatology · 2019Pooled it
- Can we cure vasculitis?Current opinion in immunology · 2025Review
- Article
- The impact of the COVID-19 pandemic on patients with systemic vasculitis: a single-centre retrospective study.Rheumatology international · 2023Article
- Classification of ANCA-associated vasculitis: differences based on ANCA specificity and clinicopathologic phenotype.Rheumatology international · 2021Review
- Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms.CNS neuroscience & therapeutics · 2021Review
- In Vitro Human Blood-Brain Barrier Model for Drug Permeability Testing.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Mechanism and biomarkers in aortitis--a review.Journal of molecular medicine (Berlin, Germany) · 2020Review
- T follicular helper cells and T follicular regulatory cells in rheumatic diseases.Nature reviews. Rheumatology · 2019Review
- Extracellular vesicles in autoimmune vasculitis - Little dirts light the fire in blood vessels.Autoimmunity reviews · 2019Review
- Endothelial activation and injury by microparticles in patients with systemic lupus erythematosus and rheumatoid arthritis.Arthritis research & therapy · 2019Article
- A Review and Hypothesized Model of the Mechanisms That Underpin the Relationship Between Inflammation and Cognition in the Elderly.Frontiers in aging neuroscience · 2019Article
- Microbiomes of Inflammatory Thoracic Aortic Aneurysms Due to Giant Cell Arteritis and Clinically Isolated Aortitis Differ From Those of Non-Inflammatory Aneurysms.Pathogens & immunity · 2019Article
- Aging in Primary Systemic Vasculitis: Implications for Diagnosis, Clinical Manifestations, and Management.Drugs & aging · 2019Review
- Pulmonary vasculitis.Journal of thoracic disease · 2018Review
- An infant presenting with Kawasaki disease following immunization for influenza: A case report.Biomedical reports · 2018Article
- Endothelial Progenitor Cells for the Vascularization of Engineered Tissues.Tissue engineering. Part B, Reviews · 2018Review
- Why location matters - site-specific factors in rheumatic diseases.Nature reviews. Rheumatology · 2017Review
- The changing face of polyarteritis nodosa and necrotizing vasculitis.Nature reviews. Rheumatology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vasculitides are a large group of heterogeneous diseases for which it has been assumed that pathogenesis is largely autoimmune. As clinicians, we distinguish one form of vasculitis from another on the basis of observed patterns of organ injury, the size of the vessels affected and histopathological findings. The terms 'small-vessel', 'medium-vessel' and 'large-vessel' vasculitis are useful clinical descriptors, but fail to inform us about why vessels of a certain calibre are favoured by one disease and not another. Classification based on vessel size also fails to consider that vessels of a specific calibre are not equally prone to injury. Distinct vulnerabilities undoubtedly relate to the fact that same-size vessels in different tissues may not be identical conduits. In fact, vessels become specialized, from the earliest stages of embryonic development, to suit the needs of different anatomical locations. Vessels of the same calibre in different locations and organs are as different as the organ parenchymal cells through which they travel. The dialogue between developing vessels and the tissues they perfuse is designed to meet special local needs. Added to the story of vascular diversity and vulnerability are changes that occur during growth, development and ageing. An improved understanding of the unique territorial vulnerabilities of vessels could form the basis of new hypotheses for the aetiopathogenesis of the vasculitides. This Review considers how certain antigens, including infectious agents, might become disease-relevant and how vascular diversity could influence disease phenotypes and the spectrum of vascular inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.