ArticleThe Journal of cell biology2014
Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Condensin complexes: from chromatin organization to disease.Nucleus (Austin, Tex.) · 2026Review
- DNA actively regulates the "safety-belt" dynamics of condensin during loop extrusion.Nature communications · 2026Article
- Mitotic genome folding.The Journal of cell biology · 2025Review
- Rules of engagement for condensins and cohesins guide mitotic chromosome formation.Science (New York, N.Y.) · 2025Article
- Rules of engagement for condensins and cohesins guide mitotic chromosome formation.bioRxiv : the preprint server for biology · 2024Article
- Cancer testis antigens: Emerging therapeutic targets leveraging genomic instability in cancer.Molecular therapy. Oncology · 2024Review
- Regulation of the mitotic chromosome folding machines.The Biochemical journal · 2022Article
- Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22BProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mitotic chromosomes.Seminars in cell & developmental biology · 2021Review
- Cdk1-dependent phosphorylation of KIF4A at S1186 triggers lateral chromosome compaction during early mitosis.PloS one · 2018Article
- Subunits of human condensins are potential therapeutic targets for cancers.Cell division · 2018Article
- Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis.Scientific reports · 2017Article
- Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold.PloS one · 2017Article
- HJURP interaction with the condensin II complex during G1 promotes CENP-A deposition.Molecular biology of the cell · 2017Article
- The functional role for condensin in the regulation of chromosomal organization during the cell cycle.Cellular and molecular life sciences : CMLS · 2016Review
- Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk.Radiology and oncology · 2016Article
- Chromosome Compaction by Active Loop Extrusion.Biophysical journal · 2016Article
- Article
- Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells.Science signaling · 2015Article
- Chromosome Dynamics during Mitosis.Cold Spring Harbor perspectives in biology · 2015Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During mitosis, genomic DNA is condensed into chromosomes to promote its equal segregation into daughter cells. Chromosome condensation occurs during cell cycle progression from G2 phase to mitosis. Failure of chromosome compaction at prophase leads to subsequent misregulation of chromosomes. However, the molecular mechanism that controls the early phase of mitotic chromosome condensation is largely unknown. Here, we show that Mps1 regulates initial chromosome condensation during mitosis. We identify condensin II as a novel Mps1-associated protein. Mps1 phosphorylates one of the condensin II subunits, CAP-H2, at Ser492 during mitosis, and this phosphorylation event is required for the proper loading of condensin II on chromatin. Depletion of Mps1 inhibits chromosomal targeting of condensin II and accurate chromosome condensation during prophase. These findings demonstrate that Mps1 governs chromosomal organization during the early stage of mitosis to facilitate proper chromosome segregation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.