ArticleInternational journal of molecular sciences2014
Role of Candida albicans-secreted aspartyl proteinases (Saps) in severe early childhood caries.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Oral Candida-biome and Early Childhood Caries: A Systematic Review and Meta-Analysis.International dental journal · 2025Pooled it
- Antifungal Activity Assessment of Postbiotic Mediators Derived From Lactobacillus rhamnosus GG and Lactobacillus reuteri Against Candida albicans.MicrobiologyOpen · 2026Article
- GcrR in Streptococcus mutans Inhibits the Morphological Transition of Candida albicans Through Ras1-cAMP/PKA Pathway in the Cross-Kingdom Biofilms.Molecular oral microbiology · 2026Article
- Evaluation of the Antifungal Activity of the Polyphenol FormulationAntibiotics (Basel, Switzerland) · 2026Article
- Role of amino acid substitutions on proteolytic stability of histatin 5 in the presence of secreted aspartyl proteases and salivary proteases.Protein science : a publication of the Protein Society · 2025Article
- Saps1-3 Antigens inInfectious disease reports · 2024Article
- Investigation of the relationship between fluconazole susceptibility, proteinase activity andCurrent medical mycology · 2024Article
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- Roles ofFrontiers in cellular and infection microbiology · 2023Review
- Article
- The effects of secreted aspartyl proteinase inhibitor ritonavir on azoles-resistant strains of Candida albicans as well as regulatory role of SAP2 and ERG11.Immunity, inflammation and disease · 2021Article
- Inhibition of Phospholipase by Orlistat as an Alternate Therapy to Combat Opportunistic Mycosis Caused by C. albicans.Current microbiology · 2021Article
- Role of Candida albicans on enamel demineralization and on acidogenic potential of Streptococcus mutans in vitro biofilms.Journal of applied oral science : revista FOB · 2019Article
- Cariogenicity of Candida albicans of distinct genotypes among 3-5-year-old Uygur children in Kashgar, China- a case-control study.BMC oral health · 2018Article
- Effect of a Lactobacillus Salivarius Probiotic on a Double-Species Streptococcus Mutans and Candida Albicans Caries Biofilm.Nutrients · 2017Article
- Role of Virulence Determinants in Candida albicans' Resistance to Novel 2-bromo-2-chloro-2-(4-chlorophenylsulfonyl)-1-phenylethanone.Journal of fungi (Basel, Switzerland) · 2017Article
- Genotypic diversity and cariogenicity of Candida albicans from children with early childhood caries and caries-free children.BMC oral health · 2015Article
- Impact of oral health behaviors on dental caries in children with intellectual disabilities in Guangzhou, China.International journal of environmental research and public health · 2014Article
- Role of Candida species from HIV infected children in enamel caries lesions: an in vitro study.Journal of applied oral science : revista FOBArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans is strongly associated with severe early childhood caries (S-ECC). However, the roles of secreted aspartyl proteinases (Saps), an important virulence factor of C. albicans, in the progress of S-ECC are not clear. In our study, the Saps activities were evaluated by the yeast nitrogen base-bovine serum albumi (YNB-BSA) agar plate method and by the MTT method with bovine serum albumin (BSA) as the substrate. Genotypes of C. albicans and gene expression of Sap1-5 were evaluated. The relationships of Saps activities and genotypes with S-ECC were analyzed. The results showed that enzyme activities of Saps in the S-ECC group were significantly higher than those in the caries free (CF) group (p<0.05). Genotypes A, B and C were detected in the S-ECC group, and genotypes A and C were detected in the CF group. In the genotype A group, Saps activity in the S-ECC group was significantly different from that in the CF group (p<0.05). The gene expression level of Sap1 in the S-ECC group was significantly higher than that in the CF group (p=0.001), while Sap4 expression was significantly lower than that in the CF group (p=0.029). It can be concluded that Sap1-5 are the predominant proteinase genes expressed in C. albicans from dental biofilm and Sap1 may play an important role in the development of S-ECC.
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