ReviewInternational journal of molecular sciences2014
Sperm-egg fusion: a molecular enigma of mammalian reproduction.
Review in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- The influence of cell-cell fusion on cancer heterogeneity and its promise for targeted treatments.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility.Biomedicines · 2024Review
- Prediction of Pesticide Interactions with Proteins Involved in Human Reproduction by Using a Virtual Screening Approach: A Case Study of Famoxadone Binding CRBP-III and Izumo.International journal of molecular sciences · 2024Article
- Molecular dynamics of JUNO-IZUMO1 complexation suggests biologically relevant mechanisms in fertilization.Scientific reports · 2023Article
- Inhibition of Mitochondrial Uncoupling Proteins Arrests Human Spermatozoa Motility without Compromising Viability.Antioxidants (Basel, Switzerland) · 2023Article
- Complementing Testicular Immune Regulation: The Relationship between Sertoli Cells, Complement, and the Immune Response.International journal of molecular sciences · 2023Review
- Expression of membrane fusion proteins in spermatozoa and total fertilisation failure during in vitro fertilisation.Andrology · 2022Article
- MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization.Science advances · 2022Article
- Mysteries and unsolved problems of mammalian fertilization and related topics.Biology of reproduction · 2022Review
- Spatiotemporal perturbations of pronuclear breakdown preceding syngamy affect early human embryo development: a retrospective observational study.Journal of assisted reproduction and genetics · 2022Observational
- Article
- Characteristics of the cytoplasmic halo during fertilisation correlate with the live birth rate after fresh cleaved embryo transfer on day 2 in minimal ovarian stimulation cycles: a retrospective observational study.Reproductive biology and endocrinology : RB&E · 2021Observational
- Role of Integrins in Sperm Activation and Fertilization.International journal of molecular sciences · 2021Review
- Expression, structure and function analysis of the sperm-oocyte fusion genes Juno and Izumo1 in sheep (Ovis aries).Journal of animal science and biotechnology · 2021Article
- Deactivation of the JNK Pathway by GSTP1 Is Essential to Maintain Sperm Functionality.Frontiers in cell and developmental biology · 2021Article
- Evaluation of the proteomic profiles of ejaculated spermatozoa from Saanen bucks (Animal reproduction · 2019Article
- RNA-seq coupled to proteomic analysis reveals high sperm proteome variation between two closely related marine mussel species.Journal of proteomics · 2019Article
- HAP2/GCS1: Mounting evidence of our true biological EVE?PLoS biology · 2018Article
- Caenorhabditis elegans sperm membrane protein interactome.Biology of reproduction · 2018Article
- Gamete compatibility genes in mammals: candidates, applications and a potential path forward.Royal Society open science · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of gamete fusion remains largely unknown on a molecular level despite its indisputable significance. Only a few of the molecules required for membrane interaction are known, among them IZUMO1, which is present on sperm, tetraspanin CD9, which is present on the egg, and the newly found oolema protein named Juno. A concept of a large multiprotein complex on both membranes forming fusion machinery has recently emerged. The Juno and IZUMO1, up to present, is the only known extracellular receptor pair in the process of fertilization, thus, facilitating the essential binding of gametes. However, neither IZUMO1 nor Juno appears to be the fusogenic protein. At the same time, the tetraspanin is expected to play a role in organizing the egg membrane order and to interact laterally with other factors. This review summarizes, to present, the known molecules involved in the process of sperm-egg fusion. The complexity and expected redundancy of the involved factors makes the process an intricate and still poorly understood mechanism, which is difficult to comprehend in its full distinction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.